Prognostic significance of lipid disorders in osteoarthritis patients

The aim of the study was to elucidate the clinicalpathogenetic significance of the levels of the oxidized low density lipoproteins (OxLDL) and antibodies against them (antiOxLDL) in patients with osteoarthritis. A total of 130 osteoarthritis patients were studied by using the enzymelinked immunosorbent assay. The high levels of OxLDL and antiOxLDL were found in 60 and 29% of patients, respectively. Patients with the high levels of OxLDL and antiOxLDL had severe polyosteoarthrosis with secondary synovitis, longer duration of the disease, and profound decline in joint function. These data may suggest a possible role of OxLDL and antiOxLDL in the pathogenesis of osteoarthritis.