Protein system of bacillus anthracis antigens
Автор: Tsekhomsky A.V., Balchevskaya A.S.
Журнал: Cardiometry @cardiometry
Рубрика: Original research
Статья в выпуске: 27, 2023 года.
Бесплатный доступ
In our research work, we have considered the structures of some anthrax antigens, their design and functions, as well as the genetic apparatus encoding them. The study is of interest to those practicing microbiologists and researchers whose area of interest includes knowledge of the regulation of infection processes and subsequent transformations of Bacillus anthracis spores in the host organism. Pathways for the expression of B. anthracis pathogenic genes, the factors influencing them, as well as ways to use patterns in gene expression to increase the immunization in experimental animals by combining various experimental vaccines, which are currently used in preventive practice in different countries of the world and in particular in the Russian Federation, are considered in detail herein. In addition, the article may be of interest to scientists and researchers conducting research in the field of creating new immunizing agents based either on the anthrax genome or some parts thereof.
Bacillus anthracis, anthrax, antigen, exotaxin, protein system
Короткий адрес: https://sciup.org/148326626
IDR: 148326626 | DOI: 10.18137/cardiometry.2023.27.8085
Список литературы Protein system of bacillus anthracis antigens
- Wikipedia, the free encyclopedia: official website – URL: https://upload.wikimedia.org/wikipedia/ commons/a/a1/Bacillus_anthracis_Gram.jpg. [Accessed 22.10.2022]
- Wikipedia, the free encyclopedia: official website – URL: https://ru.wikipedia.org/wiki/Bacillus_anthracis#/media/File:ANTHRA_1.JPG [Accessed 10/24/2022]
- Divya Goel, et al. Crp/fnr family protein binds to promoters of atxA and sodmn genes that regulate the expression of exotoxins in Bacillus anthracis. Protein Expression and Purification. 2022; 193: 106059.
- Lesnichaya MV, et al. Silver-containing nanocomposites based on galactomannan and carrageenan: synthesis, structure, antimicrobial properties. Proceedings of the Academy of Sciences. Chemical series. 2010; 12: 1-6. [in Russian]
- Erin L. Mettert, Patricia J. Kiley. Fe–S proteins that regulate gene expression. Biochimica et Biophysica Acta (BBA). Molecular Cell Research. 2015; 1853(6): 1284-93.
- Abinit Saha, Jayanta Mukhopadhyay, Ajit Bikram Datta, Pradeep Parrack. Revisiting the mechanism of activation of cyclic AMP receptor protein (CRP) by cAMP in Escherichia coli: Lessons from a subunit-crosslinked form of CRP. FEBS Letters. 2015; 589(3): 358-63.
- Colin Scott, Jonathan D Partridge, James R Stephenson, Jeffrey Green. DNA target sequence and FNR-dependent gene expression. FEBS Letters. 2003; 541(1–3): 97-101.
- Heinz Körner, Heidi J Sofia, Walter G Zumft. Phylogeny of the bacterial superfamily of Crp-Fnr transcription regulators: exploiting the metabolic spectrum by controlling alternative gene programs. FEMS Microbiology Reviews. 2003;27(5):559-92.
- Vladimir I Klichko, et al. Anaerobic induction of Bacillus anthracis hemolytic activity. Biochemical and Biophysical Research Communications. 2003; 303(3): 855-62. [in Russian]
- Spencer RC, Lightfoot NF. Preparedness and Response to Bioterrorism. Journal of Infection. 2001; 43(2): 104-10.
- Spencer RC, et al. Agents of biological warfare. Rev. Med. Microbiol. (1993)
- Inglesby TV, et al. Anthrax as a biological weapon: medical and public health management. Working Group on Civilian Biodefense. JAMA. (1999)
- D.C. Fish, et al. In vivo-produced anthrax toxin, J. Bacteriol. (1968)
- A. Kolb, et al. Transcriptional regulation by cAMP and its receptor protein, Annu. Rev. Biochem, (1993)
- J. Green, et al. Reconstitution of the [4Fe-4S] cluster in FNR and demonstration of the aerobic-anaerobic transcription switch in vitro, Biochem. J., (1996)
- N. Khoroshilova, et al. Iron-sulfur cluster disassembly in the FNR protein of Escherichia coli by O2: [4Fe-4S] to [2Fe-2S] conversion with loss of biological activity, Proc. Natl. Acad. Sci. U. S. A., (1997). [in Russian]
- Vityazeva SA, et al. Topical issues of improving the specific prevention of plague and anthrax. Epidemiology and vaccination. 2013; 4(71): 63–6. [in Russian]
- Lukyanova SV, Kravets EV, Shkaruba TT. Anthrax vaccines and prospects for their improvement. Infectious diseases. 2011; 9(1): 51–6. [in Russian]
- Popov YA, Mikshis NI. anthrax vaccines. Problems of especially dangerous infections. 2002; 1(83): 21–36. [in Russian]
- Onishchenko GG. Immunoprophylaxis – achievements and tasks for further improvement. Journal. microbiol., epidemiol. and immunobiol. 2006; 3: 58–62. [in Russian]
- Noonan S, Baker R, Hallis B, et al. (2003) Biochemical analysis of the UK licensed anthrax vaccine. Proceedings of the 5th International Conference on Anthrax.
- Goncharova AY, Mikshis NI, Popov YA. Characterization of S-layer proteins of Bacillus anthracis – promising components of chemical anthrax vaccines. Mater. International school-conference “Genetics of microorganisms and biotechnology”. Moscow, Pushchino, 2008. P. 128–129. [in Russian]
- Dubrovina VI, et al. Comparative characteristics of the effect of nanostructured argento-1-vinyl-1,2,4-triazole, argentogalactomannan and cobaltarabinogalactan on the immune response of experimental animals. Nanotechnologies and Health Protection. 2012; 3(12): 31–8. [in Russian]
- Dubrovina V.I., et al. Results of a study of the effect of the antigenic preparation Bacillus anthracis 34F2 Stern in combination with cobalt arabinogalactan on the activation and apoptosis of blood cells in vitro. Epidemiology and vaccination. 2014; 4(77):78–82. [in Russian]
- Dubrovina VI, et al. Effect of Bacillus anthracis 34F2 Sterne antigenic preparations in combination with nanocomposites on the immune response of experimental animals. Epidemiology and vaccination. 2014; 3(76)92–6. [in Russian]
- Konovalova ZhA, et al. Immunogenic properties of experimental antigenic preparations Bacillus anthracis 34F2 Stern. Mater. Vseross. scientific-practical conf. “Actual problems of preventive medicine, environment and public health”.Ufa, 2013. P. 304–307. [in Russian]
- Konovalova ZhA, et al. Influence of nanostructured argento-1-vinyl-1,2,4-vinyltriazole, cobaltarabinogalactan, argentogalactomannan on antimicrobial immunity factors. Mater. All-Russian scientific-practical conference “Fundamental and applied aspects of public health risk analysis”. Perm, 2012. P. 305–308. [in Russian]
