Early detection of clinical aspects of haemophilia and hemostasis violation in newborns

The aim of work was the definition of phasing of early diagnosis of haemophilia and disturbanses of haemostasis in newborns. Clinical manifestations of haemophilia were identified and the state of vaso platelets of haemostasis in newborns with haemophilia was evaluated. For this purpose we were defining the activated partial tromboplastin time (APTT), protrombin time (PT), activities of VIII and IX factors, platelet count, aggregation of platelets induced by ADF, adrenalin, collagen, content serotonin in platelets and its release, the induced by ADF, adrenalin and collagen. In newborns with haemophilia hemorrhages of the microcirculation type were registered. Were revealed A decrease in the aggregation functions of platelets and reactions of the serotonin release from platelets in the process of aggregation. This dictates the necessity of the correction with therapy using concentrates VIII and IX factors.