Fundamental aspects of the morphological and functional changes of the myocardium in heart failure

The article presents material of studying the fundamental aspects of morphological and functional changes of the myocardium in heart failure (HF). Authors describe results of electrophysiological, biochemical, genetic, and morphological studies performed by using material from the laboratory animals with modeling of cardiovascular pathologies and from patients with ischemic heart disease (IHD) admitted to clinic of RI Cardiology (Tomsk). Based on presented data, the associations of morphological, functional, and biochemical changes in the cardiomyocytes in the process of pathological remodeling of the myocardium are shown. Data suggest the possible association of these changes with genetic polymorphism.