Development and characterization of organic iodine and zinc derivatives

The development of effective preventive measures and treatment in conditions of natural deficit of essential microelements (iodine, zinc) is extremely relevant. An attempt of immobilization of zinc and iodine, and the creation of organic forms of microelements is made in the article. Soy protein hydrolyzate was used as an organic carrier. The conditions of enzymatic hydrolysis of soy protein are developed in the paper. Pepsin was used as an enzyme. The conditions for the immobilization of zinc and iodine have been theoretically substantiated and experimentally confirmed. 1 mg of the obtained complex contained 0.08 p.g of iodine and 1.74 mg of zinc. The methods of chemical binding of microelements with functional groups of carriers have been studied. The presence of chemical bonds and the stability of the obtained complexes are investigated. The formation of a covalent bond with zinc and an ionic bond with iodine has been established. The total energy of the complex molecule is a rather small value (-6535.689 kcal / mol), the rms gradient is slightly different from zero (0.06 kcal / А x mol), which indicates the balance of the energy properties of the system and the effective minimization of energy. The magnitude of the dipole moment (3.508 Debye) characterizes the uniformity of the electron density distribution. The obtained characteristics confirm reliability of the proposed hypothetical model. The development of new methods of immobilization and production of organic forms of microelements with a predetermined concentration ofdeficient trace elements is a priority taskfor the prevention ofdiseases associated with the lack of trace elements in various regions of the Russian Federation.