Regional chemotherapy and chemoradiotherapy in the treatment of tumors in children. The literature review

Today in many solid tumors in children the cure is not provided by the surgery, radiotherapy and systemic chemotherapy. This is due to low sensitivity of tumor cells remaining in the area of surgical intervention to applied doses of radiation therapy and to the concentrations of drugs, introduced inravenously. At the same time, few publications in the literature indicate that the use of regional chemotherapy as a single method or in combination with radiation therapy in some forms of tumors as bone and soft tissue sarcoma, retinoblastoma, tumors of the brain and liver can significantly improve the results of treatment of those patients for whom traditional methods are ineffective. The establishment of modern equipment and technologies of endovascular interventions in recent years gives reason to hope for further development of methods of regional chemotherapy and devascularization of the tumor in combination with modern radiation therapy in cases, in which the existing treatment options are doomed to failure.