The left atrium remodeling is associated with adverse outcomes in unoperated the left atrium remodeling is associated with adverse outcomes in unoperated degenerative aortic stenosis

Degenerative aortic stenosis (DAS) may be accompanied by remodeling of the left atrium (LA). The aim of the study was to assess the effect of the morpho-functional parameters of the LA remodeling on the prognosis of patients with DAS. The prospective study included 383 patients (men - 33.9% of patients), aged 78.9 ± 0.40 years, with DAS (mild - 18.3%, moderate - 30.8%, severe - 50.9%). The patients did not undergo a surgical correction of the defect. The LA morpho-functional state was estimated by the LA size/volume and the ratio of the rate of the transmitral flow to the rate of the early diastolic movement of the fibrous mitral valve ring (E/e ratio). The average follow-up period was 603.9 ± 24.57 days. The general mortality was assessed. The information on the outcomes was collected by telephone contacts. Multivariate tox-regression analyses showed that the LA remodeling was independently associated with the death risk: an increase in the LA size ≥45 mm PR 1.6, CI 1...