Research study on the efficiency of a defibrillating biphasic pulse of various durations based on mathematical modeling and simulation of a cardiomyocyte

Research study on the efficiency of a defibrillating biphasic pulse of various durations based on mathematical modeling and simulation of a cardiomyocyte

Автор: Chernov N.N., Bezverkhii A.A.

Журнал: Cardiometry @cardiometry

Статья в выпуске: 18, 2021 года.

Бесплатный доступ

The paper presents the results of our research study on the impact of different durations of a biphasic rectangular pulse on the efficiency of the defibrillating action based on modeling and simulation of a cardiomyocyte in the framework of Cell Electrophysiology Simulation Environment. We used Luo-Rudy Mammalian Ventricular Model II (dynamic) as the mathematical model of the biochemical processes, which occur both on the surface and inside a cardiomyocyte in a guinea pig. An analysis of the obtained results allowed us to determine the optimal time of the defibrillating pulse. It has been shown that a pulse of 4 ms duration has the highest efficiency. The research has been carried out directly based on the mathematical model and simulation of the cardiomyocyte that makes it possible to minimize errors which may occur in experiments on animals

Еще

Transthoracic defibrillation, biphasic pulse, current stabilization, cardiomyocyte repolarization, ventricular fibrillation

Короткий адрес: https://sciup.org/148321611

IDR: 148321611   |   DOI: 10.18137/cardiometry.2021.18.4449

Список литературы Research study on the efficiency of a defibrillating biphasic pulse of various durations based on mathematical modeling and simulation of a cardiomyocyte

  • Ringh M, Herlitz J, Hollenberg J, Rosenqvist M, Svensson L. Out of hospital cardiac arrest outside home in Sweden, change in characteristics, outcome and availability for public access defibrillation. Scandinavian journal of trauma, resuscitation and emergency medicine 2009; 17: 18.
  • Hulleman M, Berdowski J, de Groot JR, et al. Implantable cardioverter defibrillators have reduced the incidence of resuscitation for out of hospital cardiac arrest caused by lethal arrhythmias. Circulation 2012; 126: 815–21.
  • Blom MT, Beesems SG, Homma PC, et al. Improved survival after outofhospital car diac arrest and use of automated external defibrillators. Circulation 2014; 130: 1868–75.
  • Weisfeldt ML, Sitlani CM, Ornato JP, et al. Survival after application of automatic external defibrillators before arrival of the emergency medical system: evaluation in the resuscitation outcomes consortium population of 21 million. J Am Coll Cardiol 2010; 55: 1713–20.
  • Berdowski J, Blom MT, Bardai A, Tan HL, Tijssen JG, Koster RW. Impact of onsite or dis patched automated external defibrillator use on survival after out_of_hospital cardiac arrest. Circulation 2011; 124: 2225–32.
  • Nikolay N. Chernov, Aleksandr A. Bezverkhii, Vladimir I. Timoshenko. Evaluation of general repolarization of cardiomyocites with biphasic pulses of different shapes. Cardiometry. May 2020;16:80-4; DOI: 10.12710/cardiometry.2020.16.8084; WOS:000539041400010;
  • Nikolay N. Chernov, Oksana I. Korotkova, Aleksandr A. Bezverkhii. Systematic design of optimized pulse shape for transthoracic defibrillation. Cardiometry. November 2020;17:34-8; DOI: 10.12710/cardiometry.2020.17.3438;
  • Lapicque L. Denition experimentelle de l'excitabilite. Proc. Soc. deBiol. 1909;77:280-25.
  • Blair HA. On the Intensity-Time Relations for Stimulation by Electric Currents I. J. Gen. Physiol. Jul 1932;15:709-29.
  • Blair HA. On the Intensity-Time Relations for Stimulation by Electric Currents II. J. Gen. Physiol. 1932;15(6):731-55.
  • Irnich W. The fundamental law of electrostimulation and its application to debrillation. Pacing Clin Electrophysiol. Nov 1990;13:1433-47.
  • Irnich W. Optimal truncation of defibrillation pulses. Pacing Clin Electrophysiol. Jun 1995;18:673-88.
  • Schuder JC, Stoeckle H, Dolan AM. Transthoracic Ventricular Defibrillation with Squarewave Stimuli: One-Half Cycle, One Cycle, and Multicycle Waveforms. Circ Res. 1964;15(3):258-64.
  • Schuder JC, Rahmoeller GA, Stoeckle H. Transthoracic Ventricular Defibrillation with Triangular and Trapezoidal Waveforms. Circ Res. 1966;19(10):1524-71.
  • Schuder JC, et al. Transthoracic ventricular defibrillation in the 100 kg calf with symmetrical one-cycle bidirectional rectangular wave stimuli. IEEE Trans Biomed Eng. Jul 1983;30:415-22.
  • Chapman PD, et al. Strength-duration curves of fixed pulse width variable tilt truncated exponential waveforms for nonthoracotomy internal defibrillation in dogs. Pacing Clin Electrophysiol. Jul 1988;11:1045-50.
  • Bardy GH, et al. A prospective randomized evaluation of biphasic versus monophasic waveform pulses on defibrillation efficacy in humans. J Am Coll Cardiol. Sep 1989;14:728-33.
  • Kroll M. A minimal model of the single capacitor biphasic defibrillation waveform. Pacing and Clinical Electrophysiology. 1994;17:1782-92.
  • Cooper RA, et al. The effect of phase separation on biphasic waveform defibrillation. Pacing Clin Electrophysiol. Mar 1993;16:471-82.
  • Bourland JD, et al. Comparative efficacy of damped sine wave and square wave current for transchest ventricular defibrillation in animals. Med Instrum. 1978;12(1):42-5.
  • Tacker W. Defibrillation of the Heart: ICDs, AEDs, and Manual. St. Louis: Mosby - YearBook, 10 1993.
  • Wilson CM, et al. Death and Damage Caused by Multiple Direct Current Shocks: Studies in an Animal Model. European Heart Journal. 1988;9(11):1257-65.
  • Fishler M. Theoretical Predictions of the Optimal Monophasic and Biphasic Defibrillation Waveshapes. IEEE Transcadtons on Bimedical Engineering. 2000;47(1):59-67.
  • http://www.simulogic.com/products/platforms/
  • Faber GM, Rudy Y. Action Potential and Contractility in [Na+]i Overload Cardiac Myocytes. Biophysical Journal. Vol. 78 №5 pp. 2392-2404.
  • Gorbunov BB. The study of the properties of the membrane of myocardial cells on the Luo-Rudy model. Medical equipment. 2012; 3: 32—34. [in Russian]
  • Cansell A. Wirksamkeit und Sicherheit der Impulskurvenformen bei transthorakaler Defibrillation. Notfall & Rettungsmedizin. 1998; 1 (6): 372—380. http://dx.doi.org/10.1007/s100490050087
  • Normal human physiology / ed. by B. I. Tkachenko. - 2nd ed. - M.: Medicine, 2005. - P. 115. - 928 p. - ISBN 5-225-04240-6 [in Russian]
  • Gaiton A. K., Hall D. E. Medical Physiology.Textbook of Medical Physiology / Ed. IN AND. Cobrina. Moscow: Logosphere, 2008. P. 113. 1296 p. - ISBN 978-5-98657-013-6 [in Russian]
  • Bers DM. Cardiac excitation-contraction coupling. Nature. 415 (6868): 198–205. doi:10.1038/415198a
  • Koeppen BM, Stanton BA. Berne & Levy Physiology. — 6th edition. — Philadelphia: Mosby/Elsevier, 2008. — С. 295. — 834 с. — ISBN 0323045820
  • Hamill OP. Ion transport by single receptor channels. Cold Spring Harbor Symp. Quant. Biql. 1983; 48: 247-57.
Еще
Статья научная
QR-код для установки приложения SciUp Наведите камеру и скачайте бесплатное приложение SciUp