The results of radiation therapy for high-grade gliomas depending on prognostic factors

Now in the USA and Europe the standards of complex treatment for malignant brain gliomas imply the comprehensive approach, namely, a tumor is removed surgically first, then a radiotherapy course accompanied by chemotherapy, and after it a course chemotherapy is carried out. The current standard of radiation therapy in primary patients with high-grade gliomas is the traditional mode of fractionation of 2 Gy 5 times a week with total doses 54-60 Gy depending on tumor grade. We used the modified RPA model to choose programs of complex treatment for brain malignant gliomas (we call it “modified adapted model of RSCRR”). It should be noted, that the traditional fractionation of radiation therapy is preferable in I-IV classes of patients, but in the V class medium fractions (3Gy) may be used. V class patients should start getting irradiation not later than 4-6 weeks after surgery. It is important to achieve radical total doses in patients of all prognostic classes (from I to V). Fixing devices and simultaneous chemotherapy do not improve overall survival in the V prognostic group. The volume of surgical removal of brain glial tumors directly influences the overall survival rate in all prognostic classes according to our prognostic model.