The risk of oncohematological pathology in children of workers employed at radiation hazardous production

Preconceptive irradiation is considered to be a potential risk factor that can cause hemolymphoblastosis in children conceived and borne by irradiated parents. A population cohort that comprises workers employed at "Mayak" Production Association (Mayak PA), the first nuclear cycle enterprise, is a unique sampling to calculate a carcinogenic risk in their children. Our research goal was to assess risk of hemolymphoblastosis among children conceived and borne by workers employed at Mayak PA with individual preconceptive accumulated absorbed dozes. Data and methods. We performed retrospective research as per "case-control" study among all the people living in the city of Ozersk located near Mayak PA. Hemolymphoblastosis diagnosed in people younger than 25 in 1949-2009 (81 people) were considered to be "cases"; "controls were chosen taking into account sex, birth date, and parents' age when a child was borne (324 people). We calculated odds ratio and excessive relative risk per external gamma-radiation dose unit (ERR/Gy) with 95 % confidence interval; to do that, we applied PEGAN program module of EPICURE software...