Tne role of C-reactive protein and tumor necrosis factor-а in pathogenesis of atrial fibrillation in patients with arterial hypertension

Intensity of the immune response was studied in the group of patients with arterial hypertension and atrial fibrillation. Patients with arterial hypertension had higher levels of C-reactive protein (CRP) and tumor necrosis factor-α (TNFα) compared with control. The study revealed associations between the inflammatory factors (CRP and TNFα) and structural-functional myocardial changes in groups of patients with arterial hypertension and atrial fibrillation and without these. Patients with arterial hypertension and atrial fibrillation paroxysms had high levels of TNFα. The level of CRP negatively correlated with the severity of arrhythmia. Our study provided evidence that pro-inflammatory mediators are involved in the pathogenesis of atrial fibrillation in patients with arterial hypertension.