Роль генома в суицидальном поведении (обзор литературы)

Роль генома в суицидальном поведении (обзор литературы)

Автор: Козлов Вадим Авенирович, Голенков Андрей Васильевич, Сапожников Сергей Павлович

Журнал: Суицидология @suicidology

Статья в выпуске: 1 (42) т.12, 2021 года.

Бесплатный доступ

Обзор литературы посвящён анализу связи суицидального поведения как с генными локусами, так и установленными полиморфизмами генов. Рассмотрена связь с суицидами как отдельных генов, так и их групп. Особенно ценными являются сведения об однонуклеотидных полиморфизмах генов, регулирующих концентрацию кортизола (гены FKBP5, SLC6A3, CRHR1, CRHR2, SKA2), поскольку именно эта группа генов регулирует стресс-реакцию и участвует в формировании депрессивного состояния наряду с серотонин- (гены 5-HTTLPR, HTR2A) и адренергической (гены ADRA2A, ADRA2B) системами, патологию которых обычно связывают с разными формами депрессии и суицидами. Большой интерес представляют сведения, что разные полиморфизмы генов (CRHR1, CRHR2, SKA2), регулирующих концентрацию кортизола, характерны для половозрастных групп и потому определяют различия по частоте, возрасту и причинам совершения суицида. Кроме того, рассмотрена роль в реализации суицида полиморфизмов гена белков семейства YWHAE, гена нейротрофического фактора NTRK2, reward системы. Обсуждены вопросы формирования возможных путей поиска средств профилактики развития суицидального фенотипа. Авторами предложено выделить суицидальный фенотип в самостоятельную группу состояний, рассматриваемую как мультифакториальное заболевание, финальным итогом которого является совершение суицида или его попытка, требующее кодификации и нуждающееся в разработке классификации вариантов этиологии и патогенеза

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Суицид, суицидальный фенотип, генная сеть, кортизол, адреналовая система, серотониновая система

Короткий адрес: https://sciup.org/140257622

IDR: 140257622   |   DOI: 10.32878/suiciderus.21-12-01(42)-3-22

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