The role of male accessory glands infection and leukospermia in andrological practice

Introduction. The inflammatory process in the accessory male sex glands is considered as one of the factors of reducing male fertility, however, the pathogenetic mechanisms of the development of generative dysfunction in this pathology remain poorly understood. Materials and methods. The search, analysis and synthesis of relevant publications in PubMed databases was carried out, eLibrary.ru, cyberleninka.ru by keywords. As a result, 38 publications were selected, which are included in this review. Rusults. Leukospermia is detected in 10-20% of infertile men. An increase in the concentration of leukocytes in the ejaculate in response to the introduction of a bacterial infection is a marker of the inflammatory process developing in the accessory sex glands. An increase in the production of free radicals by activated leukocytes contributes to the development of oxidative stress, one of the main mechanisms of the development of male infertility. Their pathogenetic significance requires further study. It is not clear whether leukospermia and infections of the accessory sex glands have an impact on the results of assisted reproductive technologies (ART). Conclusion. Inflammation of the accessory sex glands can affect male fertility by increasing the concentration of free radicals in the ejaculate. These pathogenetic mechanisms require further study in relation to clinical practice.