The role of insulin resistance in the development of cardiovascular diabetic autonomous neuropathy in type 2 diabetes mellitus patients

Iinterrelationship between insulin resistance markers (level of insulin, TNF-? and HOMA-IR index), endothelial dysfunction and degree of vegetative dysfunction in patients having type 2 diabetes mellitus with cardiovascular form of diabetic autonomic neuropathy was studied. It was established that degree of vegetative dysfunction depend on insulin level, insulin resistance degree (increase level of TNF-? and index of HOMA-IR) and endothelial dysfunction. The study confirmed that hyperglycemia, hyperinsulinemia, insulin resistance and endothelial dysfunction result in vegetative nervous system disturbances with increased sympathetic activity.