Estrogen metabolites in the pathogenesis of breast, endometrial and ovarian cancer

Introduction: In this work was studied the relation of estrogen metabolites in urine (2-hydroxiestron/16a-hydroxiestron) in postmenopausal women. Materials and methods: 90 women without medical history of cancer, 60 patients with breast cancer, 60 patients with endometrial cancer, 67 patients with malignant epithelial ovarian tumors. The results of the study: The survey makes it possible to conclude that, in patients with breast cancer, endometrial and ovarian cancer, in contrast to the healthy women, estrogen metabolism is focused on production of "aggressive" 16a-OH metabolites. These data greatly expand the understanding of the ethiopathogenesis of cancer of the female reproductive system, with an emphasis on endocrinological factor.