Role of pathological olfaction in formation of substance dependence with different routes of drug administration

Objective. To reveal interrelationships of pathological olfaction with clinical characteristics of persons with substance use disorder and to evaluate prognostic possibilities of sensory characteristics for prediction of addictive disorders with different routes of drug administration. Materials and methods. With use of immunophysiologic methods 203 persons aged 16-29 years (persons with addictive disorders and controls) were examined. Results. Interrelationships of pathological olfaction with clinical characteristics of patients have been revealed. Prognostic models for inhalation and intravenous routes of drug administration with use of sensory characteristics and clinical signs of immune deficiency have been proposed. Conclusion. Anamnestic olfactory preferences are a sign of mild severity of substance-related disorders. Sensory characteristics have prognostic possibilities for prediction of addictive disorders with different routes of drug administration.