The role of polymorphism in the calsequestrin gene in the development of atrial fibrillation and sick sinus syndrome

At present, special attention is given to studying the role of genetic factors in the development of cardiovascular diseases. Wide implementation of the genetic and cellular technologies in the future may contribute to solving the problem of prevention and treatment of cardiac arrhythmias. Ion transport systems in the cardiomyocytes play an important role in the regulation of homeostasis of myocardial cells. The literature describes polymorphic variants in the calsequestrin gene associated with arrhythmias, sudden cardiac death, and development of heart failure in patients with ischemic heart disease. Objective: The objective of the study was to analyze the role of polymorphism in the calsequestrin 1 gene in the development of atrial fibrillation (AF) and sick sinus syndrome (SSS). The study included 47 patients aged 67.0±15.4 years (38 men (80.8%)). Among these patients, 15 individuals (31.9%) had AF; 11 patients (23.4%) had SSS; and 21 patients (44.6%) had combination of these pathologies. These patients had coronary artery disease (n=27 (57.4%)), hypertension (n=10 (21.2%)), myocarditis (n=3 (6.4%)), and idiopathic heart rhythm disturbances (n=7 (14.9%)). Only 35 patients had C/C genotype and 12 patients had C/T genotype. The frequencies of the C and T alleles in patients with a combination of AF and SSS were 88% and 12%, respectively. The frequencies of the C and T alleles in AF group were 93% and 7%, respectively. The frequencies of the C and T alleles in SSS group were 77% and 23%, respectively. Conclusion. The findings showed no significant associations of AF and SSS with the polymorphisms in the calsequestrin gene.