The role of T-511C polymorphism in the IL-1P gene in patients with arterial hypertension and metabolic syndrome and its association with the risk of developing chronic heart failure

Introduction. This article analyzes the role of polymorphism T-511C genes of IL-1P cytokine for identification of genetic determinants of an increased risk for developing the chronic heart failure (CHF) in patients with arterial hypertension (AH) and metabolic syndrome (MS). Materials and Methods. 246 people with CHF signs were examined. All the patients were diagnosed on anamnestic data and clinical signs. The patients were divided into two groups: cases with AH with MS (180 people) and cases with AH without MS (66 people). The age of patients was 57,2 ± 2,68. The control group consists of 60 relatively healthy people. As the genetic study material, the DNA samples were taken from lymphocytes of peripheral venous blood. The study of polymorphic loci was conducted using polymerase chain reaction (PCR) with the subsequent electrophoretic detection. Results. It was found that S-allele and genotype C/C of polymorphic loci of T-511C gene IL-1P are associated with the inchasing risk of development, severity of clinical aspects and unfavorable character of CHF course in patients with AH and MS. Discussion and Conclusions. The obtained data can play a significant role in early detection of cardiovascular events, in particular AH-MS-CHF that has great importance for effective preventive measures of the risk of serious sequels and objective assessment of the prospects for treatment.