Role of hypothalamic-pituitarygonadal regulatory axis in growth of melanoma B16/F10 in C57/Bl6 mice
Автор: Kit O.I., Bandovkina V.A., Frantsiyants E.M., Kaplieva I.V., Cheryarina N.D., Pozdnyakova V.V., Trepitaki L.K., Pogorelova Y.A., Kachesova P.S., Gusareva M.A., Bosenko E.S., Kuchkina L.P., Saforiyn N.S., Kuznetsova M.S.
Журнал: Cardiometry @cardiometry
Рубрика: Original research
Статья в выпуске: 27, 2023 года.
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Aim: to study the role of the hypothalamic-pituitary-gonadal (HPG) regulatory axis and its dermal analogue in C57BL/6 mice of both sexes with the growth of B16/F10 grafted melanoma. The studies were carried out in mice of both sexes of the C57BL/6 line, which were transplanted with B16/F10 melanoma by subcutaneous injection of 0.5 ml of a suspension of tumor tissue. In intact animals and in the animals 14 days after the tumor inoculation, the levels of gonadal releasing hormone (GnRH), LH and FSH, and estradiol (E2), total testosterone (T) and free testosterone (Tfr), progesterone (P4), as well as ERα and ERβ estrogen receptors, progesterone receptor (RP4) and androgen receptor (RA) were determined. Results. In the males, compared with the females, after melanoma transplantation, the latent period and average life spans were shorter, while their tumor volumes were larger. A 2.1-fold decrease in GnRH in the hypothalamus in males led to a 2.7- fold increase in the level of LH in the pituitary gland, while in females a 1.4-fold (p
B16/f10 melanoma, hypothalamic-pituitary-gonadal axis, regulatory peptides, steroid hormones, receptors
Короткий адрес: https://sciup.org/148326622
IDR: 148326622 | DOI: 10.18137/cardiometry.2023.27.4753
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