Статьи журнала - Saratov Medical Journal
Все статьи: 102
Статья научная
Objective: to carry out a comparative assessment of risk factors, target organ damage, and gestational outcomes in pregnant women with HTN and normal blood pressure (BP). Materials and Methods. The prospective cohort study included 88 pregnant women distributed among two groups: Group 1 (main group) included 44 women with white coat HTN), while Group 2 (comparison group) comprised 44 women with normal BP). We performed an assessment of clinical factors, 24-hour BP monitoring parameters, damage to target organs (heart, kidneys, and blood vessels), and pregnancy course and outcomes. Results. Women with white coat HTN vs. normotensive pregnant females had a higher prevalence of abdominal obesity (90.9% vs. 47.7%; p<0.001) and history of preeclampsia (11.4% vs. 0%; p=0.021); higher systolic (SBP) and diastolic BP (DBP) during daytime (p<0.001) and at night (p=0.006); higher daytime heart rate (p=0.006); thicker left ventricular posterior wall (p<0.001) and interventricular septum (p<0.001); greater relative wall thickness of the left ventricle (LV) (p=0.003); higher LV myocardial mass (p<0.001) and LV end-diastolic volume (p=0.020); thicker intima-media of blood vessels on the right (p=0.022) and left (p=0.006); and higher value of the right cardio-ankle vascular index (p=0.043) and urine albumin/creatinine ratio (p<0.001). The course of pregnancy in women with white coat HTN was more often aggravated by gestational diabetes mellitus (79.5% vs. 25%; p<0.001) and late-onset preeclampsia (11.4% vs. 0%; p=0.021). Conclusion. Pregnancy in women with white coat HTN is characterized by an increased risk of developing structural and functional changes in target organs and a high frequency of complications vs. normotensive pregnant women.
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Статья научная
Objective: to assess the concentration of the sST2 biomarker and its relationship with the morphological and functional parameters of the LV myocardium in patients with coronary artery disease (CAD) and functional class (FC) I-III chronic heart failure (CHF), who survived COVID-19 or did not experience it. Materials and Methods. We examined 100 patients (66 males) of median (Me) age of 65 [63; 67] years with stable CAD and FC I-III CHF (sensu New York Heart Association), distributed among two groups depending on the presence of COVID-19 in their anamneses. Along with the conventional clinical examination, the concentration of serum sST2 was determined via ELISA. Results. We revealed that in patients surviving COVID-19 (Group 1), the sST2 level was 38.4 [35.5; 44.8] ng/mL, while in the comparison group (Group 2), it amounted to 29.63 [27.9; 32.7] ng/mL (p<0.001). In Group 1, the end-diastolic volume and the end-systolic volume of the left ventricle (LV) significantly exceeded values of these parameters in Group 2 (p=0.004 and p=0.02, respectively) and amounted to 118.2 [107.5; 166.5] mL and 44.1 [35.0; 58.1] mL, correspondingly, in Group 1 and 107.5 [92.4; 129.5] mL and 37.9 [29.5; 47.4] mL in Group 2. The number of patients with grade 2 diastolic dysfunction (DD) in Group 1 (18–33.9%) significantly exceeded that in the comparison group (7%–14.9%). Changes in global longitudinal strain (GLS) of the LV in Group 1 (-15.6 [-20.8; -13.8] %) were more pronounced than in the comparison group (-19.9 [-21.5; -16.3] %), p=0.018. Conclusion. CAD patients with FC I-III CHF, who survived COVID-19, had statistically significantly higher serum sST2 concentration, more pronounced LV DD, and greater LV GLS.
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