Статьи журнала - Saratov Medical Journal
Все статьи: 77
A novel approach to initial hearing assessment
Статья научная
Objective: justifying the possibility of using frequency-based hearing research via the web application ‘Automated System for Initial Hearing Assessment’. Materials and methods. The study was carried out at the Department of Otorhinolaryngology of the Samara State Medical University clinics in October 2019. It involved 91 patients 17 to 73 years old (average age 48±14.6 years). All study participants were divided into two age groups: Group I 17-59 years old), and Group II (over 60 years old). Patients were required to undergo two hearing assessment tests: using the Interacoustics AC-40 clinical audiometer and using our web application ‘Automated System for Initial Hearing Assessment’ (patent No. 2019664671). Results. The maximum difference in average hearing thresholds between pure-tone threshold audiometry and the web application in Group I was 3.3 dB at a frequency of 2 kHz on the right and 3.2 dB at frequencies of 2 and 4 kHz on the left; in Group II, it constituted 4.7 and 3.5 dB at 1 and 2 kHz, on the right, correspondingly, and 7.2 dB at 4 kHz on the left. The presented data were evaluated using the Cohen’s kappa coefficient, which confirmed high level of agreement between the results obtained using the clinical audiometer vs. our original web application. Conclusion. Based on the obtained results, a conclusion was made about the possibility of using the original web application for the initial hearing express assessment in general practice in conditions of limited availability of audiological care.
Бесплатно
Статья научная
Objective: To develop a prognostic algorithm for nocturnal hypoglycemia (NH) based on data from a mobile glucose monitoring application. Materials and Methods. A retrospective analysis of 524 continuous glucose monitoring (CGM) profiles of patients with type 1 diabetes mellitus was performed. CGM was performed using the Medtronic iPro2 system for 6-7 days, and the night periods of CGM were analyzed to identify regular NH. The study included 239 patients, of whom 65 (27.1%) experienced regular NH. We constructed the models of 7-point glycemic profiles, the data from which were uploaded to the DiaLog GM mobile application to calculate conventional glucose monitoring parameters. The prognostic model of NH was developed using the logistic regression method. Results. Based on the regression analysis, the most significant predictors of NH included in the prognostic model were glycated hemoglobin level (p=0.001), use of insulin pump therapy (p=0.001), time below the target time in range (TIR) for blood glucose content of level 1 (p<0.001), and the coefficient of variation for glucose content (p=0.02). The area under the ROC curve for the prediction model was 0.917; the optimal cut-point value for the predicted probability of NH was 0.317, at which the sensitivity of the model was 86%, and its specificity was 90%. Conclusion. Due to its higher predictive ability, the developed prediction model based on the data of a specialized mobile application allows improving existing approaches to assessing the risk of NH.
Бесплатно
Advances in dermatology research: A comprehensive literature review
Статья научная
In recent years, the field of dermatology has seen significant advances in our understanding of disease pathogenesis, diagnostic techniques, and therapeutic interventions. The objective of this literature review is to provide an overview of ten key subtopics in contemporary dermatology research. First, I examined cutting-edge developments in skin cancer detection and treatment, acne and psoriasis management strategies, and the evolving therapeutic landscape for atopic dermatitis. Additionally, we delve into the clinical significance of skin manifestations associated with systemic diseases and analyze emerging trends in cosmetic dermatology. Further on, we discuss innovations in wound healing, diagnosis and treatment of hair disorders, and dermatological conditions unique to pediatric patients. Finally, we explore the role of telemedicine in dermatology practice, highlighting its potential to revolutionize patient care and access to specialty services. Through a synthesis of the current literature, this review offers insight into forefront dermatology research and emphasizes the importance of continued innovation to improve patient outcomes and quality of care.
Бесплатно
Статья научная
Objective: to identify the expression patterns of immunohistochemical markers, CD3, CD68, CD163 and CK-19, in thymus cells of neonates with an enlarged thymus who died from infectious diseases. Materials and Methods. The study material was autopsy material of infants of the early and late neonatal periods (n=33) who died in medical hospitals of Saratov. The causes of death were pneumonia (n=17) and sepsis (n=16). The morphological material was divided into two groups: Group 1 (comparison group) included children whose thymus gland weight corresponded to the age norm (n=19); Group 2 (study group) comprised children whose thymus weight exceeded the age norm (n=14). The study assessed the expression of the following markers: CD3, CD68, CD163 and CK-19. Results. We established that with an increase in the thymus mass, the proportion of CD3+ cells in its cortex exhibited a 2.7-fold increase (p=0.009), the proportion of CD68+ cells demonstrated almost threefold increase (p=0.009), whereas the share of CD163+ cells diminished by 10% (p=0.005) and CK-19 positive cells did not form a network. Conclusion. An increase in the thymus mass in infants of the early neonatal period with infectious diseases is accompanied by disruption in the processes of lymphocyte migration and differentiation.
Бесплатно
Статья научная
Objective: to evaluate the bacteriostatic properties of the developed prototypes of thin-film coating for orthopedic implants made of titanium and its alloys. Materials and Methods. Using scanning electron microscopy, we examined the morphology of Ti-6AL-4V (ASTM F1472) samples with a thin-film coating containing cupric oxide nanoparticles with a dispersion of 50-70 nm applied to their surface by plasma electrolytic oxidation. Then we assessed the impact of prototypes of thin-film coating on the propensity of clinical strains of microorganisms to adhere and form biofilms, and on their growth properties. Results. The developed prototype of a thin-film coating caused a significant decrease in the mass of biofilms formed by clinical strains of various microorganisms by 11% (Staphylococcus aureus), 38% (Staphylococcus epidermidis) and 7% (Pseudomonas aeruginosa), along with a reduction in bacterial growth properties by 12.7 % (S. aureus), 13.3% (S. epidermidis) and 10% (P. aeruginosa). Conclusion. The developed prototype of a thin-film coating for products made of titanium and its alloys reduced the virulence factors of clinical microbial strains due to its pronounced bacteriostatic effect via inhibiting bacterial adhesive activity and their ability to form biofilms.
Бесплатно
Antimicrobial activity of toothpastes against early childhood caries
Статья научная
Objective: assessing antimicrobial activity of toothpastes with different ingredient composition recommended for infants and toddlers. Materials and Methods. The study object was dental plaque of children with decompensated form of caries under the age of 3 years old. Seven toothpastes with different composition designed for early childhood were studied. Identification of detected microorganisms was carried out via mass spectrometry. Antibacterial activity was determined by agar diffusion and serial dilution methods. Results. Toothpastes containing xylitol, lactic enzymes and ingredients of medicinal herbs exhibited the absence of a microbial growth inhibition zone. Fluoride toothpastes were active against all tested microorganisms, and the final fluoride inhibitory concentration was 0.00016-0.0025%, depending on the fluoride concentration in the toothpaste. Conclusion. The least pronounced antimicrobial activity was detected in complex toothpastes with lactic enzymes and ingredients of medicinal herbs, as well as in samples with xylitol. Simple toothpastes with organic and inorganic fluorine compounds demonstrated the best bactericidal effect.
Бесплатно
Статья научная
Background: Primary open-angle glaucoma (POAG), the leading cause of blindness in India, has an insidious onset and lack of early symptoms often leading to late diagnosis, which highlights the need for effective screening methods. The specific cause is associated with irreversible damage to the optic nerve due to increased intraocular pressure. Visual evoked potentials (VEPs) are electrophysiological tests used to measure the electrical responses generated in the visual cortex in response to visual stimuli. Objective: To evaluate the utility of VEP testing as a screening tool to detect early cases of glaucoma. Materials and Methods: This case-control study aimed to evaluate pattern-reversal visual evoked potentials (PRVEPs) in early cases of POAG compared with healthy controls. Our study sample included 30 patients diagnosed with POAG who, together with age-matched controls, were tested for VEPs. Results. Significant delays in N70, P100 and N145 latencies were observed in the POAG group vs. the controls. The results showed significant differences in VEP parameters between the control and case groups. The latencies of N70, P100 and N145 were prolonged in patients with POAG, indicating a delay in nerve conduction along the visual pathway. Although the decrease in P100 amplitude was not statistically significant, the changes in latency were highly significant. Conclusion: VEPs may serve as a valuable screening tool for early neuro-ophthalmic deficits in the detection and monitoring of glaucoma in tertiary care hospitals, facilitating timely intervention and preventing irreversible vision loss in patients with glaucoma.
Бесплатно
Associations of TNFSF11 gene polymorphisms with knee osteoarthritis in postmenopausal women
Статья научная
Objective: to identify the role of rs9594738 and rs9594759 polymorphisms of the TNFSF11 gene in the development of osteoarthritis (OA) of the knee joints (KJ) in postmenopausal women. Materials and Methods. Our case-control study involved 483 postmenopausal women. Of these, 157 were diagnosed with primary KJ OA. The remaining 326 women without signs of joint disease were included in the control group. Molecular genetic studies included the determination of rs9594738 and rs9594759 polymorphisms of the TNFSF11 gene using the real-time polymerase chain reaction method. Results. Analysis of the distribution of genetic markers in two groups of women demonstrated a reduction in the frequency of occurrence of the TT genotype of the rs9594738 polymorphism among patients with OA (odds ratio 0.59; 95% confidence interval 0.36-0.97; p=0.049). The distribution of the alleles of this polymorphism, as well as the alleles and genotypes of the rs9594759 polymorphism of the TNFSF11 gene in the group of women with OA, did not differ significantly from the results of the molecular genetic examination of the control group (p>0.05). Conclusion. We established an association between the rs9594738 polymorphism of the TNFSF11 gene and KJ OA in postmenopausal women. Further studies of the role of polymorphic variants of the TNFSF11 gene in the etiopathogenesis of KJ OA are needed to develop individual approaches to the prevention and treatment of this disease.
Бесплатно
Automated map of reproductive losses in the Far North region of Russia
Статья научная
Objective: to compile an automated map of reproductive losses in the Far North regions of Russia. Material and methods: This article includes statistical analysis of the prevalence and structure of reproductive losses according to the worldwide, Russian, and regional statistics. After describing the general structure of a neural network with a radial basis and a model of a radial neuron, we proceeded to characterization of the error backpropagation algorithm. Hence, our study was based on the normal deviation function. Results. The article substantiates the problem of reproductive losses of the Russian population. On the basis of statistical data, the listing of a neural network program for an interactive map of reproductive losses in the Far North regions of the Russian Federation was built. The obtained data made it possible to identify risk zones in the region. Comparison of indicators for 2000 and 2022 helped revealing the dynamics of change and reporting valid information on the overall increase in the risk of reproductive losses in the region by 17%. Conclusion. We proposed to conduct monitoring of reproductive loss indicators in the regions of the Russian Federation on the basis of a neural information map construction. The compiled map is an interactive map with an assessment of reproductive loss dynamics over the years.
Бесплатно
Статья научная
The objective of our study was to evaluate the cerebroprotective effect of xanthohumol (ХN) on experimental models of acute ischemic stroke in vivo and in vitro. Materials and methods. We used middle cerebral artery occlusion (MCAO) and oxygen-glucose deprivation (OGD) as in vivo and in vitro models. Our study subjects were Sprague-Dawley rats, which were randomly assigned to three groups: the control group and two MCAO groups with and without XN. The primary culture of cortical neurons was obtained from newborn rats. We employed the Bederson test and the corner test to evaluate neurological disorders. Results. The preliminary results indicated a possible cerebroprotective effect of XN in an ischemic stroke model. Conclusion. Preventive administration of XN before cerebral ischemia in an experiment can effectively reduce the volume of cerebral infarction and improve neurologic deficit 24 hours after MCAO.
Бесплатно
Change in brain electrical activity connectivity in migraine patients without aura
Статья научная
Objective: In this study, we consider how the structure of the brain EEG activity changes in patients with migraine, compared with virtually healthy volunteers without complaints of acute or chronic headache. Materials and Methods. The study of the connectivity of EEG activity was carried out on the basis of an objective assessment of pairwise synchronization between different recording channels, for which we used a method based on wavelet bicoherence. Results. Within the framework of the performed experimental study, we demonstrated an increased reactivity in the structure of connections in brain electrical activity of the patients experiencing a weak visual impact. Conclusion. A prospective study could determine the value of the described diagnostic procedure in support of the clinical decision on appropriate pharmacological and non-pharmacological prophylactic measures.
Бесплатно
Статья научная
Objective: to conduct a comparative analysis of mitochondrial respiration in brain homogenates of rats with stepwise incomplete cerebral ischemia (SICI) with varying duration between ligations of both common carotid arteries (CCA). Material and methods. The experiments were performed on 24 male mongrel white rats weighing 260±20 g. All rats were distributed among three subgroups. Cerebral ischemia was simulated under intravenous thiopental anesthesia (40-50 mg/kg). The control group (n=6) comprised sham-operated rats of similar gender and weight. To study mitochondrial respiration, the brain was extracted in the cold environment (0-4 °C), dried with filter paper, weighed and homogenized sensu the modified technique in an isolation medium containing 0.32 M sucrose, 10 mM Tris-HCl, 1 mM EDTA, pH of 7.4 (in a ratio of 1:10), using Potter – Elvehjem homogenizer with Teflon pestle. Results. SICI with an interval of 1 and 3 days between ligation of both CCA led to neuronal damage in the parietal cortex and hippocampus of rats, which manifested itself in a reduction of the neuron size, deformation of the perikaryons, an increase in the number of shrunken neurons and shadow cells. The most pronounced changes were observed in the subgroup with one-day interval between ligations. These changes were similar to the changes in incomplete cerebral ischemia (ICI) (p=0.07), except for the absence of cells with pericellular edema in the hippocampus and a smaller number of those in the parietal cortex. ICI with seven-day interval between ССА ligations, on the contrary, was manifested by less pronounced histological changes, especially in the hippocampus. Conclusion. Comparative analysis of mitochondrial respiration in brain homogenates revealed that the severity of brain damage in SSIC depended on the interval between blood flow arrest in both CCA. At the same time, the highest level of energy metabolism disorder was observed during CCA ligation with an interval of one day, which implied insufficient implementation of compensatory mechanisms.
Бесплатно
Changes in the amino acid pool of cerebral hemispheres in rats with total cerebral ischemia
Статья научная
Objective: assessment of changes in the pool of amino acids (AA) in rats with totalcerebral ischemia (TCI). Materials and Methods. Experiments were performed on 16 male outbred white rats weighing 260±20 g. TCI was modeled by decapitation of animals. Brain tissue was sampled 1 hour after decapitation. Results. In the parietal lobe (PL) and hippocampus (HC) of TCIgroup animals 1 hour aftertheir decapitation, we detected an increase in the content of tyrosine (by 43%, p=0.044, and 40%, p=0.044, respectively) and tryptophan (by 24%, p=0. 036, and 23%, p=0.046, respectively). Similar trend was observed for methionine that increased by 32% in PL (p=0.046) and by 27% in HC (p=0.046). Analogous increase in the content of L-arginine was noted in PL and HC (by 20%, p=0.037, and 33%, p=0.037, correspondingly). Isoleucine content increased by 12% in PL (p=0.054), whilevaline content decreased by 15% in HC (p=0.053). The ratio of the combined total content of branched-chain amino acids (BCAA) to the combined content of aromatic AA in TCI significantly declined from 1.4 to 1.0 in PL (p=0.053) and from 1.6 to 1.0 in GC (p=0.053). We observed an increase in methionine content by 33% (p=0.046) in PL and an increase in tryptophan content by 24% (p=0.046) in HC. Conclusion. One-hour TCIcaused the following changes in the AA pool: an increase in the content of aromatic AA (tyrosine and tryptophan) and methionine; an increase in the content of L-arginine; and also, an increase in the concentration of the inhibitory neurotransmitter glycine.
Бесплатно
Статья научная
Objective: to evaluate the activity of oxidative stress in rats with stepwise incomplete cerebral ischemia (SICI). Material and methods. Experiments were performed on 24 male outbred rats weighing 260±20 g, allocated into 3 subgroups (6 animals in each) based on time of ligation of both common carotid arteries (CCA). The control group comprised of sham-operated rats of the same sex and similar weights (n=6). To identify the pro-oxidant–antioxidant state of the brain based on its homogenates, the activity of lipid peroxidation processes, the content of thiobarbituric acid reactive substances (TBARS), the concentration of reduced glutathione (GSH), total thiol groups (TSH), and the activity of glutathione peroxidase were determined. Results. SICI with ligation interval of both CCAs of 1 day and 3 days led to a significant decrease in the total SH groups of proteins and glutathione by 30% (p=0.038) and 46% (p=0.044), respectively, TBARS concentration by 29% (p=0.038) and 31% (p=0.043), respectively. SICI with the maximum interval between CCA ligations was manifested by less pronounced changes in the pro-oxidant–antioxidant state of the brain. Conclusion. In SICI with ligation of both CCAs 7 days apart, at which histological changes were the least pronounced, changes in the pro-oxidant–antioxidant balance were insignificant. The most pronounced disorders of the pro-oxidant–antioxidant balance in the brain were observed in the subgroup with the minimum interval between CCA ligations, which implied the highest activity of oxidative stress.
Бесплатно
Статья научная
The objective was to assess the effectiveness of the use of transcranial magnetic therapy in comprehensive non-drug recuperation of neonates with perinatal injury of the central nervous system. Materials and Methods. Our research involved 214 newborns with corrected age of 30 weeks of gestation and perinatal lesion of the central nervous system. Main group (n=79): neonates underwent standard pharmacotherapy in combination with comprehensive non-drug recuperation (which included dry immersion, music therapy and orolingual massage), and transcranial magnetic therapy. Comparison group (n=74): newborns underwent standard pharmacotherapy in combination with non-drug recuperation. Control group (n=61): infants received conventional pharmacotherapy. Results. In Main group, hyperexcitability syndrome was healed in 60% of infants, and autonomic visceral disorders were cured in 80% of children. CNS depression syndrome signs disappeared in 67% of neonates. A significant (p<0.05) decrease in the resistance index was noticed, along with reduction in elevated peripheral vascular resistance and expansion of physiological reflexes, especially of the oral automatism group. Odds ratio of normalization of oral reflexes by day 10 for Main group vs. Control group was 5.09 with 95% CI [1.8-13.8]; and for Main group vs. Comparison group, it was 3.0 with 95% CI [1.1-8.4]. Normalization of muscle tone and resistance index reduction by day 10 in Main group was observed 8 and 4 times more often, correspondingly, than in Control group. Odds ratios were 8.2 with 95% CI [1.8-16.3] and 4.05 with 95% CI [1.06-9.3], respectively. Conclusion. Non-drug recovery methods in combination with magnetic therapy generated the sedative effect; provided stimulation of respiratory movements and spontaneous motor activity; and contributed to restoring proper reflex action. Hence, they are recommended for inclusion in the perinatal CNS lesion therapy of neonates.
Бесплатно
Cognitive disorders in patients with chronic kidney disease in pre-dialysis period
Статья научная
Objective: to study the cognitive status of patients in the pre-dialysis period depending on the stage of chronic kidney disease (CKD) and the category of cardiovascular risk (CVR). Materials and Methods. We examined 98 patients with CKD in the pre-dialysis period (mean age 47.1±11.2 years). The patients were divided into three groups according to the criteria of CVR stratification. Group 1 consisted of 32 patients with a low or moderate CVR, and CKD stage C1 or C2; Group 2 included 34 patients with a high CVR and CKD stage C3a or C3b; Group 3 comprised 32 patients with a very high CVR and CKD stage C4. We used the SAGE test (Self-Administered Gerocognitive Examination) to evaluate cognitive functions. Results. Cognitive impairment (CI) was detected in 57% of the patients: 37.5% in Group 1, 44.1% in Group 2, and 90.5% in Group 3. Dementia was diagnosed in 19% of patients with CI. A correlation was found between the severity of CI, the degree of decrease in glomerular filtration rate, and the education level of CKD patients in the pre-dialysis period (p≤0.001). We established that the examined subjects with CKD were characterized by memory, constructive, spatial and logical thinking disorders. Conclusion. Chronic kidney disease is an independent risk factor for the development of CI. The latter progressed with both CKD stage and the patient’s CVR category, and was detected in 37.5% of patients with a low or moderate CVR, 44.1% of patients with a high CVR, and 90.5% of patients with a very high CVR.
Бесплатно
Статья научная
The objective of our study was to investigate the features of circulatory autonomic regulation in the patients with a coronary artery bypass graft surgery (CABG) or correction of a valvular heart disease (CVHD). Material and Methods. Our study enrolled 42 patients (including 12 women) aged 63 (57; 67), who underwent CABG; and 36 patients (including 16 women) aged 58 (47; 65), who underwent CVHD. Simultaneous 15-minute recordings of electrocardiograms and photoplethysmograms (PPG) were performed on all patients before and after the surgery. We assessed and analyzed statistical and frequency-related measures of heart rate variability (HRV) and index of synchronization (S) among low-frequency (LF) oscillations in HRV and PPG. Results. The values of most autonomic regulation indices in our study did not have statistically significant differences among the patients with CABG and CVHD at all stages of research. The exception was represented by the heart rate, which was higher before CVHD (p=0.013). Conclusion. In all patients with CABG, the values of HRV and S did not depend on the differences in their clinical statuses or performed cardiac surgical interventions.
Бесплатно
Comparative efficiency of various molecular genetic methods in diagnosing tuberculosis
Статья научная
Objective – to compare the efficacy of various molecular genetic methods for diagnosing tuberculosis and determining drug susceptibility to rifampicin (RIF). Materials and Methods. We conducted a retrospective study of the sputum analysis results on 1,992 patients with pulmonary tuberculosis treated at Saratov Oblast Clinical Tuberculosis (TB) Dispensary from 2014 through 2018. The following methods were used: real-time polymerase chain reaction (PCR), biological microarrays, automated Xpert® MTB/RIF technology. Statistical processing of the research results was carried out using the Bayes formula based on contingency tables (four-field table) and the χ2 test. When evaluating the significance of differences between relative values, we employed the critical significance level of 0.05. Results. In terms of etiological diagnosis of TB, higher diagnostic sensitivities of the real-time PCR and biological microarray methods (73.9% and 70.3%, correspondingly) were established, as compared with the Xpert® MTB/RIF method (34.2%) (p<0.001). The sensitivity of all methods depended on the massiveness of bacterial excretion and clinical form of TB. Conclusions: The Xpert MTB/RIF method exhibited lower diagnostic sensitivity in verifying the diagnosis of TB, whereas its operational characteristics in terms of determining RIF-resistance were sufficiently high (sensitivity at 89.7%, specificity at 89.1%, and efficacy at 89.4%), which was comparable with the characteristics of biological microarray method (93.9%, 71.8%, 82.9%; p=0.127, p<0.001, p=0.139, respectively).
Бесплатно
Comparative evaluation of bone defect replacement methods in revision total knee arthroplasty
Статья научная
Objective: to evaluate the immediate and long-term outcomes of revision total knee arthroplasty using porous metaphyseal sleeves and cones. Materials and Methods. The study included 134 patients who underwent revision total knee arthroplasty. The patients were distributed among two groups based on the type of metaphyseal fixator: sleeves (Group I, n=97 patients) and cones (Group II, n=37 patients). Surgical outcomes were assessed upon discharge from the hospital (after the hospital stay of 7-12 days), as well as after 6, 12 and 24 months after surgery. The survival rate of endoprostheses was analyzed using the Kaplan–Meier method. A revision with total replacement of the endoprosthesis or its components was considered a critical event. Results. The analysis of the survival rate of endoprostheses in the form of various metaphyseal fixators showed that the groups of sleeves and cones did not differ statistically significantly as suggested by the logrank test (Mantel–Cox): p=0.108. Conclusion. The midterm follow-up revealed no difference in clinical, functional, or radiological outcomes of revision total knee arthroplasty performed for types 2A, 2B, and 3 of bone defect replacement (sensu Anderson Orthopaedic Research Institute classification) using trabecular metal metaphyseal cones vs. sleeves.
Бесплатно
Статья научная
Objective: to evaluate the hospital outcomes of coronary artery bypass grafting using autoarterial and autovenous conduits. Materials and Methods. We conducted a randomized clinical trial. We used the left internal thoracic artery for bypassing the anterior interventricular branch in both groups. The remaining conduits were either only the radial artery or the radial artery and great saphenous vein (study group) or solely the great saphenous vein (control group). The investigated outcomes were, among others, in-hospital mortality, Type 5 myocardial infarction, cerebrovascular event, respiratory failure, bleeding, cardiac arrhythmias, and acute kidney injury (AKI). Results. A sample of 27 patients was randomly distributed among the study group (n=12) and the control group (n=15). According to the perioperative and early postoperative data, there were no statistically significant differences between the groups, except for the duration of stay on artificial ventilation in intensive care unit: in the study group, it was longer than in the control group: 14 (12; 18) h versus 9.3 (5.8; 13) h, p=0.034. The most common complications were cardiac arrhythmias and AKI. There were no statistically significant differences between groups regarding studied for outcomes. Postoperative hospital stay (expressed as number of bed days) also did not differ statistically significantly between groups. Conclusion. According to our data, in the first days after surgery, the use of the radial artery does not provide significant advantages compared to the use of the great saphenous vein.
Бесплатно
