Synergism of antioxidant complexes components for prevention and treatment of male infertility

Introduction. Currently, there has been an increase in the number of people suffering from infertility, while 20-50% of childless couples have problems associated with reproductive disorders in men. In Russia for the period 2000-2018. there was an increase in the number of men with infertility by 2.1 times. Male fertility is largely determined by the process of spermatogenesis. The importance of oxidative stress in the etiology of sperm dysfunction is now generally accepted and unquestioned. The aim of the work was to study the role of oxidative stress in male infertility and the possibility of using exogenous antioxidants to improve sperm quality. Materials and methods. Publications were searched in the MEDLINE international database on the PubMed platform, in the scientific electronic libraries eLIBRARY.ru and CYBERLENINKA.ru by keywords: male infertility, semen, antioxidants, tocopherol, L-carnitine, L-arginine, zinc, selenium, folic acid, Wifertyl asset (male infertility, semen, antioxidants, tocopherol, L-carnitine, L-arginine, zinc, selenium, folic acid, Wifertyl active). In total, more than 1000 works were found, 68 articles published in the last 10-15 years were selected. Results. Imbalance in the formation of reactive oxygen species and the state of antioxidant protection of the body in men can lead to disorders of spermatogenesis, which plays a decisive role in the development of male infertility. Moreover, oxidative stress can have a major impact on the health and well-being of future generations. Using exogenous antioxidants, control of the formation of free radicals can be achieved, and the combined use of compounds with different mechanisms allows acting on different levels of antioxidant protection and increases the effectiveness of therapy. Complex use of antioxidants allows to reduce the dose of each of them, which increases the safety of treatment. When developing combination drugs to improve male reproductive function, it is necessary to take into account not only the effect on spermatogenesis of individual components, but also their interaction with each other, since when using several antioxidants at the same time, there is a risk of undesirable interactions. Biocomplex Wifertyl Active is an improved version of the Wifertyl complex, which includes N-acetyl-L-carnitine, L-arginine, coenzyme Q, selenium, zinc, vitamins E, C, V9, D3, V6 and V12. The effectiveness of Wifertyl in the treatment of male infertility has been proven in the clinic. The new combination contains more N-acetyl-L-carnitine and L-arginine, as well as coenzyme Q10. Vitamin doses were also adjusted. Conclusion. Biocomplex Wifertyl Active is an example of a rational combination of various antioxidants. The compounds included in its composition limit the damaging effect of reactive oxygen species (ROS) by enhancing various links of the antioxidant system. At the same time, the components increase the efficiency of each other.