Sorption activity of polysorb VP and carbon enterosorbent modified with polyarginine, on the example of E. coli and S. aureus under in vitro conditions

The spread of infectious diseases in animals, the widespread use of antibacterial drugs, and the emergence of antibiotic-resistant strains of microorganisms determine the search for new approaches to treatment and prevention. The purpose of this study is a comparative assessment of the sorption activity of Polysorb VP and Carbon enterosorbent modified with polyarginine in relation to some pathogens of infectious diseases. In the in vitro study, the test cultures of Staphylococcus aureus ATCC 6538-P FDA 209-P and Escherichia coli M-17 were used. Suspensions were prepared from daily agar test cultures in isotonic sodium chloride solution, then they were poured into test tubes, where the test preparations of 100 mg were previously introduced. Test tubes with a microbial suspension without drugs served as a control. The exposure of the microbial suspension and the tested preparations was 30 and 60 minutes. When using Polysorb VP, the concentration of S. aureus decreased by 91.5 % after 30 minutes compared to the control sample and by 99.4 % at 60-minute exposure. For E. coli, the sorption efficiency was 41.7 % after 30 minutes and 79.2 % after 60 minutes. At the same time, the carbon enterosorbent modified with polyarginine sorbed S. aureus less effectively, but was more effective against E. coli.