The state of the liver detoxification system in calves after the use of Creolin-X

The aim of the research was to study the state of the detoxification system of the liver of calves when using the combined insectoacaricidal preparation Creolin-X. The results of the studies showed that after a single spraying of calves with Creolin-X emulsion of 1 % and 0.2 % concentrations, the general condition and behavior of the experimental animals did not change, signs of oppression, toxicosis, and death of the calves were not observed. After spraying calves with Creolin - X 1 % concentration, there are slight fluctuations in the amount of bilirubin, urea and total protein (P≥0.05). After applying Creolin-X, after 7 days there was a significant increase in the activity of the enzymes GlDH, ALT and LDH in the blood of calves. On the 15th day of the study, a significant increase in the activity of GlDH, alkaline phosphatase and ALT was observed. There were slight fluctuations in the de Ritis coefficient, the R index and the Schmidt coefficient. On day 31, unreliable changes in biochemical parameters in the blood serum of calves were noted. After spraying calves with Creolin - X 0.2 % concentration, there are slight fluctuations in the amount of bilirubin, urea, total protein, enzyme activity, de Ritis coefficients, Schmidt (KSh) and R index (P≥0.05). Creolin-X in a 0.2 % concentration does not cause changes in the biochemical parameters of the blood of calves and does not disrupt the metabolism and activity of blood enzymes in calves. The results of the study indicate that Creolin-X, with the recommended method of application, does not lead to the development of pathological reactions, and also does not have a toxic effect on the liver and body of calves, as evidenced by the dynamics of changes in biochemical parameters under experimental calves. The dynamics of biochemical parameters indicates the active participation of the liver in the metabolism of Creolin-X, and the acricidal drug does not have a hepatotoxic effect.