Synthesis and metabolism of glucocorticoid hormones in patients of young age groups having laryngeal cancer

Synthesis and metabolism of glucocorticoid hormones in patients of young age groups having laryngeal cancer have been studied. According to the results, in male patients with laryngeal cancer malignant growth is accompanied with increase of cortisol level, its main metabolic products (THF and THE) and its direct precursor 11 deoxycortisol excreted in the form of THS. Mechanism of cortisol accumulation in peripheral blood is based on intensification of its synthesis by cortex of adrenal glands and on disturbance of conjugation with remnants of glucuronic and sulphuric acids.