Status of intestinal microbiota in psoriatic disease

Objective. The aim of the study is to investigate small intestine bacterial overgrowth (SIBO) in patients with psoriatic disease. Materials and Methods. Diagnosis of psoriasis was carried out on the basis of physical examination of patients using test for psoriatic triad symptoms. Assessment of disease severity was conducted by means of generally accepted Psoriasis area severity index (PASI). According to the index value 3 psoriasis severity levels were distinguished: mild, medium and severe. The study enrolled 100 patients with psoriasis aged 19 to 75 years (mean age 41,8 years). They received medical treatment in a clinical setting of Ulyanovsk regional dermatovenerologic dispensary in 2012-2014. The experimental group enrolled 20 apparently healthy people. Microbiological study of small intestine contents from patients was conducted to detect SIBO. Results and Discussion. The results obtained showed the presence of bacteria in small intestine aspirates: more than 105 CFU/ml in 70 % of patients with psoriasis (70 people). This data indicate SIBO in patients. Conclusion. The assessment of the data suggests that there is a correlation between severity of psoriatic process according to PASI index and intensity of SIBO in the small intestine (R=0,46) as well as between duration of disease and PASI (R=0,45).