Современное состояние проблемы диагностики и лечения диффузно растущих глиом ствола мозга у детей и подростков

Современное состояние проблемы диагностики и лечения диффузно растущих глиом ствола мозга у детей и подростков

Автор: Регентова О.С., Щербенко О.И.

Журнал: Вестник Российского научного центра рентгенорадиологии Минздрава России @vestnik-rncrr

Рубрика: Обзоры

Статья в выпуске: 1 т.19, 2019 года.

Бесплатный доступ

Диффузно растущие опухоли ствола мозга относятся к числу наиболее тяжелых и, на сегодняшний день, практически неизлечимых заболеваний. В настоящее время их диагностика главным образом основывается на данных клинико-рентгенологического исследования. Лучевая терапия остается единственным реальным средством временной стабилизации роста опухоли и увеличения сроков жизни. Длительность достигаемого при этом эффекта зависит от степени агрессивности опухоли. При возобновлении роста опухоли повторная лучевая терапия в большинстве случаев позволяет улучшить качество жизни больного и увеличить ее продолжительность, но ее стратегия (показания, дозирование, сопроводительная терапия) пока не разработана, что обусловливает редкость ее использования. Применение существующих химиопрепаратов не внесло существенных изменений в результаты лучевой терапии. Надежда на повышение эффективности лечения связана с начатым в последнее время изучением молекулярно-генетических особенностей опухоли, что создаст основу для создания методик таргетной терапии.

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Дети, ствол мозга, опухоли, лучевая терапия, химиотерапия, качество жизни, молекулярно-генетическе особенности, таргетная терапия

Короткий адрес: https://sciup.org/149132092

IDR: 149132092

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