Современные представления о роли тромбоцитарных факторов в стимуляции регенерации ран

Современные представления о роли тромбоцитарных факторов в стимуляции регенерации ран

Автор: Супильников А.А., Сергеев А.Н., Морозов А.М., Аносова Е.Ю., Яремин Б.И., Штырева П.А.

Журнал: Хирургическая практика @spractice

Рубрика: Обзоры литературы

Статья в выпуске: 3 т.9, 2024 года.

Бесплатный доступ

Цель. Проанализировать применение биологических факторов в стимуляции процесса заживления ран. В ходе исследования был проведен анализ актуальных отечественных и зарубежных литературных источников по заданной теме.Материалы и методы. Анализ информационных источников проводился по ключевому запросу «Роль биологических факторов в стимуляции раневого процесса» на базе поисковых систем eLibrary и PubMed.Результаты. В настоящее время арсенал применяемых средств широк и разнообразен, используют как традиционные, так и экспериментальные методы: усовершенствованные повязки, тканевые матрицы, факторы роста (ФР), клеточную терапию и нанотехнологии. В процессе заживления ран несколько межклеточных, внутриклеточных и внеклеточных сигнальных механизмов регулируют различные фазы заживления.Заключение. Применение тромбоцитов в разных областях медицины дало многообещающие результаты при определенных заболеваниях, таких как острые и хронические повреждения костей и хрящей. Тем не менее до настоящего времени препараты на основе тромбоцитов не нашли широкого клинического применения. Ряд исследований доказывает участие тромбоцитов и связанных с ними продуктов - PMPs и экзосом - в различных фазах заживления ран. Наличие в тромбоцитарных гранулах большого количества биологически активных молекул, обладающих противовоспалительными, ангиогенными, пролиферативными и другими свойствами, делает тромбоциты привлекательными для использования в регенеративной медицине, в том числе для стимуляции заживления ран

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Биологические факторы заживления, раны, prp-терапия, раневой процесс

Короткий адрес: https://sciup.org/142242582

IDR: 142242582   |   УДК: 591.169.2   |   DOI: 10.5922/2223-2427-2024-9-3-5

New perspectives on the role of platelet factors in enhancing wound regeneration

Aim. To analyze the use of biological factors in the stimulation of the wound healing process. In the course of the study, we analysed relevant domestic and foreign literature sources on the given topic.Methods. The literature was reviewed using the key query ‘the role of biological factors in wound healing stimulation’ through the eLIBRARY and PubMed databases.Results. Currently, the range of therapeutic approaches is broad and diverse, incorporating both traditional and experimental methods such as advanced dressings, tissue matrices, growth factors (GFs), cell therapy, and nanotechnology. The wound healing process is regulated by a complex interplay of intercellular, intracellular, and extracellular signalling mechanisms across various phases of healing.Conclusion. The application of platelet-based therapies in different medical fields has shown promising outcomes in certain conditions, such as acute and chronic injuries of bone and cartilage. However, platelet-based preparations have yet to gain widespread clinical use. Several studies have demonstrated the involvement of platelets and related products, such as platelet microparticles (PMPs) and exosomes, in multiple phases of wound healing. The presence of a substantial number of biologically active molecules within platelet granules-exhibiting anti-inflammatory, angiogenic, proliferative, and other properties-renders platelets particularly attractive for use in regenerative medicine, including the stimulation of wound healin

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