Nerve tissue specific proteins in evaluation of brain damaged when performing aortic arch surgery under continuous hypothermic perfusion

The research into the dynamics of neuron-specific proteins in peripheral blood of 16 patients after aortic arch surgery and in 22 patients after coronary artery bypass grafting has demonstrated that an increase in S-100b and NSE (neuron-specific enalaze) levels observed immediately after surgery under extracorporeal circulation is related with a simultaneous impact of hypoxia and oxidative stress on permeability of the hematoencephalic barrier. Despite a more pronounced laktatemia and peroxidant activity when performing aortic arch surgery under continuous perfusion, normalization of the neuron-specific proteins in blood by the end of the first postoperative day, as well as the absence of significant differences in S100 protein levels in the groups gives evidence to the effectiveness of anesthetic brain protection applied.