Способ создания модели варикоцеле в хроническом эксперименте

Автор: Цуканов Ю.Т., Маслюков А.В., Теленков В.Н., Лубягина Е.В., Цуканов А.Ю.

Журнал: Экспериментальная и клиническая урология @ecuro

Статья в выпуске: 3 т.17, 2024 года.

Бесплатный доступ

Введение. Варикоцеле диагностируют у каждого седьмого подростка старше 15 лет, а в совокупности им страдает до 15% всех мужчин. Связь варикоцеле с мужским бесплодием мало изучена, однако нарушения показателей спермограммы у бесплодных мужчин с варикоцеле могут варьировать от нормозооспермии до полной азооспермии. Это определяет актуальность дальнейшего изучения и создания экспериментальных моделей данного заболевания на животных с целью изучения механизма его возникновения, патофизиологии ассоциированных с ним состояний, а также решения вопроса профилактики и лечения. Цель исследования: создание модели стойкого варикоцеле у лабораторного животного в хроническом эксперименте.

Еще

Варикоцеле, модель варикоцеле, животные, кролики-самцы, бесплодие, хронический эксперимент

Короткий адрес: https://sciup.org/142243270

IDR: 142243270 | DOI: 10.29188/2222-8543-2024-17-3-15-22

Список литературы Способ создания модели варикоцеле в хроническом эксперименте

Su JS, Farber NJ, Vij SC. Pathophysiology and treatment options of varicocele: an overview. Andrologia 2021;53:e13576. https://doi.org/10.1111/and.13576.
Roque M, Esteves SC. Effect of varicocele repair on sperm DNA fragmentation: a review. Int Urol Nephrol 2018;50(4):583-603. https://doi.org/10.1007/s11255-018-1839-4.
Baichorov EH, Panchenko RI. Varicocele as a factor of violation of spermatogenesis and decrease in male fertility. Astrakhan Medical Journal 2023;18(1):6-16. https://doi.org/10.29039/1992-6499-2023-1-6-16.
Agarwal A. Finelli R, Durairajanayagam D, Leisegang K, Henkel R, Salvio G, Aghamajidi A, et al. Comprehensive Analysis of Global Research on Human Varicocele: A Scientometric Approach. World J Mens Health 2022;40:e28. https://doi.org/10.5534/wjmh.210202.
Rupin S, Ashok A, Parviz K, Rambhatla A, Saleh R, Cannarella R, et al. Consensus and Diversity in the Management of Varicocele for Male Infertility: Results of a Global Practice Survey and Comparison with Guidelines and Recommendations. World J Mens Health 2023;(1):164-97. https://doi.org/10.5534/wjmh.220048.
Цуканов А.Ю., Семикина С.П., Мустафаев Р.Ф. Варикоцеле как проявление синдрома дисплазии соединительной ткани. Урологические ведомости 2019;9(2):11-6. [Tsukanov A.Yu., Semikina S.P., Mustafayev R.F. Varicocele as a manifestation of connective tissue dysplasia syndrome. Urologicheskiye vedomosti = Urology Reports 2019;9(2):11-6. (In Russian)]. https://doi.org/10.17816/uroved9211-16.
Панченко И.А., Панченко Р.И., Байчоров Э.Х. Варикоцеле: оптимальный лечебно-диагностический подход и медицинская реабилитация репродуктивной функции. Курортная медицина 2014;(4):47-53. [Panchenko I.A., Panchenko R.I., Baichorov E.Kh. Varicocele: optimal treatment and diagnostic approach and medical rehabilitation of reproductive function. Kurortnaya meditsina = Resort Medicine 2014;(4):47-53. (In Russian)].
Жуков О.Б., Верзин А.В., Пеньков П.Л. Регионарная почечная венная гипертензия и левостороннее варикоцеле. Андрология и генитальная хирургия 2013;(3):29-37. [Zhukov O.B., Verzin A.V., Penkov P.L. Regional renal venous hypertension and left-sided varicocele. Andrologiya i genital'naya khirurgiya = Andrology and genital surgery 2013;(3):29-37. (In Russian)].
Chiba K, Fujisawa M. Clinical Outcomes of Varicocele Repair in Infertile Men: A Review. World J Mens Health 2016;34(2):101-9. https://doi.org/10.5534/wjmh.2016.34.2.101.
Jensen CFS, Ostergren P, Dupree JM, Ohl DA, Sonksen J, Fode M. Varicocele and male infertility. Nat Rev Urol 2017;14:523-33. https://doi.org/10.1038/nrurol.2017.98
Morini D, Spaggiari G, Daolio J, Melli B, Nicoli A, De Feo G, et al. Improvement of sperm morphology after surgical varicocele repair. Andrology 2021;9(4)1176-84. https://doi.org/10.1111/andr.13012.
Park JH, Pak K, Park NC, Park HJ. How Can We Predict a Successful Outcome after Varicocelectomy in Painful Varicocele Patients? An Updated Meta-Analysis. World J Mens Health 2021;39(4):645-53. https://doi.org/10.5534/wjmh.190112.
Finelli R, Leisegang K, Kandil H, Agarwal A. Oxidative Stress: A Comprehensive Review of Biochemical, Molecular, and Genetic Aspects in the Pathogenesis and Management of Varicocele. World J Mens Health 2022;40(1):87-103. https://doi.org/10.5534/wjmh.210153.
Practice Committee of the American Society for Reproductive Medicine; Society for Male Reproduction and Urology. Report on varicocele and infertility: a committee opinion. Fertil Steril 2014;102(6):1556-60. https://doi.org/10.1016/j.fertnstert.2014.10.007.
Sofikitis NV, Miyagawa I, Incze P, Andrighetti S. Detrimental effect of left varicocele on the reproductive capacity of the early haploid male gamete. J Urol 1996;156:267-70.
Agarwal A, Hamada A, Esteves SC. Insight into oxidative stress in varicocele-associated male infertility: part 1. Nat Rev Urol 2012;9:678-90. https://doi.org/10.1038/nrurol.2012.197.
Ferhat K, Fazilet K, Cem A. Experimental varicocele induces hypoxia inducible factor-1, vascular endothelial growth factor expression and angiogenesis in the rat testis. J Urol 2004;172(3):1188-91. https://doi.org/10.1097/01.ju.0000135455.97627.15.
Hamada A, Esteves SC, Agarwal A. Insight into oxidative stress in varicocele-associated male infertility: part 2. Nat Rev Urol 2013;10:26-37. https://doi.org/10.1038/nrurol.2012.198.
Turner TT. The stady of varicocele through the use the animal models. Hum Reprod Update 2001;7(1):78-84. https://doi.org/10.1093/humupd/7.1.78.
Chen Q, Zhou R, Yang C, Jiang Q, Yuan H, Qiu X, et al. Ergothioneine attenuates varicocele-induced testicular damage by upregulating HSP90AA1 in rats. J Biochem Mol Toxicol 2023;37(4):e23301. https://doi.org/10.1002/jbt.23301.
Niloofar Dehdari Ebrahimi, Sara Shojaei-Zarghani, Ehsan Taherifard Sanaz. Protective effects of melatonin against physical injuries to testicular tissue: A systematic review and meta-analysis of animal models. Front Endocrinol 2023;14:1123999. https://doi.org/10.3389/fendo.2023.1123999.
Najari BB, Li PS, Ramasamy R, Katz M, Sheth S, Robinson B, Goldstein M. Microsurgical Rat Varicocele Model. J Urol 2014;191(2):548-53. https://doi.org/10.1016/j.juro.2013.08.011.
Цуканов А.Ю. Патент на изобретение. Способ моделирования варикоцеле. Заявка № 2005114330/14. [Tsukanov A.Yu. Patent for invention. Method for modeling varicocele. Application No. 2005114330/14. (In Russian)].
Zhou T, Cao H, Chen G, Yang B, Sun Y. Outcomes of experimental rat varicocele with and without microsurgery. BMC Urology 2015;15(1):19. https://doi.org/10.1186/s12894-015-0012-y.
Цуканов Ю.Т., Цуканов А.Ю., Щеглов А.Ю., Мозговой С.И. Патоморфологические аспекты варикозного поражения вен нижней половины туловища. Вестник Санкт-Петербургского университета 2006;(3):50-61. [Tsukanov Yu.T., Tsukanov A.Yu., Shcheglov A.Yu., Mozgovoy S.I. Pathomorphological aspects of varicose veins of the lower half of the body. Vestnik Sankt-Peterburgskogo universiteta = Bulletin of St. Petersburg University 2006;(3):50-61. (In Russian)].
Цуканов Ю.Т., Цуканов А.Ю., Баженов В.Н., Корниенко И.Ф., Василевич В.В. Медикаментозная коррекция негативных флеботропных эффектов гормонозаместительной терапии у женщин. Ангиология и сосудистая хирургия Журнал им. академика А.В. Покровского 2009;15(3):87-91. [Tsukanov Yu.T., Tsukanov A.Yu., Bazhenov V.N., Kornienko I.F., Vasilevich V.V. Drug correction of negative phlebotropic effects of hormone replacement therapy in women. Angiologiya i sosudistaya khirurgiya Zhurnal im. akademika A.V. Pokrovskogo = Angiology and Vascular Surgery Journal named after academician A.V. Pokrovsky 2009;15(3):87-91. (In Russian)].
Chang IY, Kim JH, Park KH, Yoon SP. Experimental varicocele induces p53-dependent germ cell apoptosis through activation of γ-H2AX. Urol Int 2010;85(2):216-20. https://doi.org/10.1159/000316356.
Arena S, Minutoli L, Arena F, Nicotina PA, Romeo C, Squadrito F, et al. Polydeoxyribonucleotide administration improves the intra-testicular vascularization in rat experimental varicocele. Fertil Steril 2012;97(1):165-8. https://doi.org/10.1016/j.fertnstert.2011.10.007.
Najari BB, Li PS, Ramasamy R, Katz M, Sheth S, Robinson B, et al. Microsurgical rat varicocele model. J Urol 2014;191(2):548-53. https://doi.org/10.1016/j.juro.2013.08.011.
Katz MJ, Najari BB, Li PS, Goldstein M. The role of animal models in the study of varicocele. Transl Androl Urol 2014;3(1):59-63. https://doi.org/10.3978/j.issn.2223-4683.2014.01.07.
Guo WB, Yang C, Bian J, Xia H, Yang JK, Zhou QZ, et al. With a new clip technique surgically inducing varicocele in Sprague-Dawley rats. BMC Urol 2018;18(1):58. https://doi.org/10.1186/s12894-018-0350-7.
Lorian K, Kadkhodaee M, Kianian F, Abdi A, Seifi B. Administration of sodium hydrosulfide reduces remote organ injury by an anti-oxidant mechanism in a rat model of varicocele. Iran J Basic Med Sci 2020;23(2):236-43. https://doi.org/10.22038/ijbms.2019.39727.9412.
Akkan SS, İzgüt-Uysal VN, Çakır T, Özbey Ö, Üstünel İ. The effect of experimental varicocele on the apelin and APJ expressions in rat testis tissue. Tissue Cell 2020;63:101318. https://doi.org/10.1016/j.tice.2019.101318.
Hosseini M, Shaygannia E, Rahmani M, Eskandari A, Golsefid AA, Tavalaee M, et al. Endoplasmic Reticulum Stress (ER Stress) and Unfolded Protein Response (UPR) Occur in a Rat Varicocele Testis Model. Oxid Med Cell Longev 2020;2020:5909306. https://doi.org/10.1155/2020/5909306.
Antonuccio P, Micali A, Puzzolo D, Romeo C, Vermiglio G, Squadrito V, et al. Nutraceutical Effects of Lycopene in Experimental Varicocele: An «In Vivo» Model to Study Male Infertility. Nutrients 2020;12(5):1536. https://doi.org/10.3390/nu12051536.
Antonuccio P, Marini HR, Micali A, Romeo C, Granese R, Retto A, et al. The Nutraceutical NPalmitoylethanolamide (PEA) Reveals Widespread Molecular Effects Unmasking New Therapeutic Targets in Murine Varicocele. Nutrients 2021;13(3):734. https://doi.org/10.3390/nu13030734.
Babaei A, Asadpour R, Mansouri K, Sabrivand A, Kazemi-Darabadi S. Lycopene protects sperm from oxidative stress in the experimental varicocele model. Food Sci Nutr 2021;9(12):6806-17. https://doi.org/10.1002/fsn3.2632.
Karimi H, Asghari A, Jahandideh A, Akbari G, Mortazavi P. Effects of Metformin on Experimental Varicocele in Rats. Arch Razi Inst 2021;76(2):371-84. https://doi.org/10.22092/ari.2020.128136.1406.
Shaygannia E, Nasr-Esfahani MH, Sotoodehnejadnematalahi F, Parivar K. Is ferroptosis involved in ROS-induced testicular lesions in a varicocele rat model? Basic Clin Androl 2021;31(1):10. https://doi.org/10.1186/s12610-021-00125-9.
Dehdari Ebrahimi N, Shojaei-Zarghani S, Taherifard E, Dastghaib S, Parsa S, Mohammadi N, et al. Protective effects of melatonin against physical injuries to testicular tissue: A systematic review and meta-analysis of animal models. Front Endocrinol (Lausanne) 2023;14:1123999. https://doi.org/10.3389/fendo.2023.1123999.
Kay R, Alexander NJ, Baugham WL. Induced varicoceles in rhesus monkeys. Fertil Steril 1979;31:195-9.
Saypol DC, Howards SS, Turner TT, Miller Jr ED. Influence of surgically induced varicocele on testicular blood flow, temperature, and histology in adult rats and dogs. J Clin Invest 1981;68(1):39-45. https://doi.org/10.1172/jci110252.
Harrison RM, Lewis RW, Roberts JA. Testicular blood flow and fluid dynamics in monkeys with surgically induced varicoceles. J Androl 1983;4:256-60. https://doi.org/10.1002/j.1939-4640.1983.tb02363.x.
Dandia SD, Bagree MM, Vyas CP, Singh H, Pendse AK, Joshi KR. Experimental production of varicocele and its effects on testis. JAP J Sur 1979;4:372-8. https://doi.org/10.1007/bf02468639.
Cockett AT, Al-Juburi A, Altebarmakian V, Vergamini RF, Caldamone AA. The varicocele: new experimental and clinical data. Urol 1980;15:492-5. https://doi.org/10.1016/0090-4295(80)90011-4.

Еще

Статья научная