Clinical effectiveness of complex treatment vesicovaginal fistula using of the platelet reach autoplasma, compared to standard approach to fistuloplasty

Background: Vesico-vaginal fistulae (VVF) are one of the most relevant and socially significant problems in modern medicine, being associated with severe impairment of patients' quality of life and profound disability. Aim of the study: to determine the efficacy of local interstitial autologous platelet-rich plasma use in combined treatment of VVF. Materials and methods: The study included 52 patients who were surgically treated for VVF. Mean age of patients was 47,3 years. Subjects were divided into 2 groups: group 1 - 30 patients (standard protocol (SP) fistuloplasty), group 2 - 22 patients (local interstitial therapy with autologous platelet-rich plasma (APRP) prior to scheduled surgical treatment). Results. Groups' baseline parameters are similar (p>0,05). In APRP group mean catheter removal time was 7,14 days (± 4,1 days), while in SP group it was 11,1 days (±2,4 days). Operative time in PRP group was 95 minutes (±52 minutes), in SP group - 121,7 minutes (±31,5 minutes) (p