Comparative analisis of the protective therapectic effect between embryonic tissue secretome - mixture proteins and peptides -and transplantation of neonatal kidney tissue in acute post-ishemic renal failure

Introduction. Regenerative medicine is an actively developing field. The possibility of treating chronic diseases with stem cell transplantation and therapy with products of their secretion is being studied. In this study we compared the effectiveness of therapy in rats with severe acute renal failure (ARF) using course administration of protein-peptide secretome (PPS) isolated from the brain of pig embryos and by transplanting tissue homogenate of neonatal kidneys of newborn rats. Materials and methods. In experiments on 36 white male rats, ARF was simulated by unilateral nephrectomy and 90-minute ischemia of the remaining kidney. In the 1st series (10 rats), therapy was not performed, in the 2nd series (10 rats), immediately after restoring blood flow in the kidney PPS was subcutaneously administered at a dose of 0.1 mg/kg followed by daily administration of the drug for 10 days, and in the 3rd series (10 rats) before restoring blood supply to the kidney, a homogenate of the kidney tissue of newborn rats was injected under its capsule...