Comparative assessment of antigenic activity and immunogenicity of Chlamydia psittaci vaccine strains on laboratory animals

The aim of the study was to conduct comparative studies of the antigenic activity and immunogenicity of C. Psittaci strains "RS-85", "250" and "AMK-16". The study of antigenic activity showed that all the studied strains cause the production of specific chlamydial antibodies in immunized animals. The highest antibody titer in CSC was found in animals immunized with the vaccine preparation from the AMK-16 strain. As a result of comparative studies of the immunogenicity of monovaccines based on the studied strains, it was found that the average value of the protection index in the group of animals immunized with the vaccine based on the strain "250" was 2.8, in the group immunized with the drug from the strain "RS-85" - 3.26. The highest protection index was found in the group of white mice immunized with a vaccine based on the AMK-16 strain (protection index 3.6).