Comparative Analysis of Laboratory Parameters in Liver Cirrhosis

The article presents the results of a retrospective analysis of 75 inpatient medical records of patients diagnosed with Child–Pugh Class C liver cirrhosis in the therapeutic department of the GAUZ Angapov National Clinical Hospital of Emergency Medical Service for the year 2024. The study has assessed gender, age, etiology of cirrhosis, biochemical parameters (albumin, creatinine, bilirubin, alkaline phosphatase, AST), coagulation profile (INR), and complete blood count (leukocytes, platelets). The study included 40 men and 35 women, with a mean age of 52 years. Patients were divided into four groups: toxic cirrhosis, toxic + viral, viral, and other (cryptogenic) for comparative analysis of biochemical parameters. Statistical processing of the data was performed using MedCalc software via correlation analysis (correlation coefficient) and t-test for independent samples. The results has shown that the lower liver's protein-synthetic function, the worse the renal function, and the higher the risk of hypocoagulation (bleeding). Higher bilirubin and AST levels (cytolysis syndrome) were correlated with elevated cholestasis indicators. The risk of hypocoagulation (bleeding) increased with the severity of cytolytic syndrome (bilirubin level). Elevated hepatocyte destruction markers (ALT) were observed more frequently in viral cirrhosis compared with other etiologies, with lower levels in toxic cirrhosis. A statistically significant increase in the risk of hypocoagulation has been found in toxic cirrhosis compared to viral forms. The risk of infectious complications was higher in toxic cirrhosis than in viral cirrhosis. Renal dysfunction was more pronounced in viral cirrhosis compared to toxic cirrhosis. A significant decrease in platelet count was confirmed in viral cirrhosis compared with toxic and other forms. Reduced albumin levels were observed across all cirrhosis etiologies. Enhanced outpatient follow-up and consistent laboratory and instrumental monitoring are necessary to prevent complications.