Stable coronary heart disease and chronic periodontitis: clinical and microbiological parallels

Purpose: in patients with stable coronary heart disease (CHD) and chronic periodontitis (CP) of varying severity, to assess the clinical and laboratory status and endothelial functions in comparison with the clinical, instrumental and microbiological characteristics of the periodontium. Material and Methods. 120 patients with CHD and CP were examined; 55 were with CP without somatic pathology, 30 were with CHD and intact periodontal disease. Results. In CHD in combination with mild CP, the level of C-reactive protein (4.5±1.5 mg / l), indicators of endothelial functions (endothelin-1: 4.5±1.6 ng / ml; sICAM-1: 429.6±90.8 ng / ml; sVCAM-1: 932.2±137.4 ng / ml; endothelium-dependent vasodilation (EDV): 9.5±1.9 %), characteristics of common carotid artery intima-media thickness (CCA IMT): 0.8±0.3 mm correspond to those in CHD without CP. CHD in combination with moderate and severe CP is associated with more severe dyslipidemia, high levels of C-reactive protein (8.8±4.7 mg / L); endothelial dysfunction (endothelin-1: 5.8±1.9 ng / ml; sICAM-1: 489.7±98.1 ng / ml; sVCAM-1: 1012.5±184.6 ng / ml; EDV: 8.6±1.8 %), increased CCA IMT: 0.90±0.20 mm. Conclusion. Stable coronary artery disease in combination with moderate and severe CP compared with coronary heart disease without CP and coronary heart disease with mild CP is associated with more severe dyslipidemia, vascular wall remodeling and endothelial dysfunction. Endothelial dysfunction in patients with coronary heart disease, like the activity of periodontitis, is associated with periodontal colonization by P. gingivalis and T. forsythia