Association between genetic polymorphisms within the serotonergic system, depression and coronary artery disease (review)

The study of comorbid depression in patients with coronary artery disease (CAD) is pivotal since its high incidence and prognostic significance for the underlying disease. Currently, biological mechanisms of depression and its relationship with coronary artery disease are not clearly defined, which is associated with a variety of predisposing and pathogenetic factors. The review discusses the role of genetic polymorphisms within the serotonergic system in the development of comorbid depression in patients with coronary artery disease.