Correlation between apoptosis level and estrogen receptor expression in breast cancer

Tissue homeostasis in mammary gland is maintained by balance between proliferation and apoptosis. This balance disappeared in breast cancer tissue. Apoptosis level in breast cancer tissue significantly positively correlates with estrogen receptors expression level in ductal breast cancer and decreases in lobular cancer after neoadjuvant chemotherapy. Spontaneous apoptosis positively correlates with proliferative activity in breast cancer tissue (correlates with G2M stage). In aneuploid tumors, spontaneous apoptosis positively correlates with the ploidy index, but does not differ in diploid and aneuploid tumors.