Тандемные масс-спектрометры в биохимии

Тандемные масс-спектрометры в биохимии

Автор: Веренчиков А.Н., Краснов Н.В., Галль Л.Н.

Журнал: Научное приборостроение @nauchnoe-priborostroenie

Рубрика: Масс-спектрометрия для биотехнологии

Статья в выпуске: 2 т.14, 2004 года.

Бесплатный доступ

В обзоре кратко рассмотрена история развития тандемной масс-спектрометрии (МС-МС) и выявлен быстрый прогресс в этой области, особенно в последнее десятилетие. Инструментальные аспекты МС-МС затронуты при описании принципов и аналитических характеристик наиболее популярных тандемов. Показан ряд приложений МС-МС в различных областях "науки о жизни", включая фармацевтику и протеомику. Особое внимание уделено динамике развития области и взаимному влиянию инструментальной базы и приложений. Значительный прогресс в развитии тандемных инструментов, как и революционный взрыв в биоинформатике сделали МС-МС наиболее чувствительным и специфическим и, как следствие, предпочтительным аналитическим методом в биохимии. В свою очередь биотехнология создала значительный рынок для (МС-МС)-приборов и стала существенно влиять на их развитие. В обзоре сделан акцент на то, что биотехнологи работают со сложными смесями (до 10^6 компонент), в большом динамическом диапазоне концентраций (до 10^6). Природа биотехнологических задач требует еще более совершенной (МС-МС)-аппаратуры, способной обеспечить более высокую чувствительность, специфичность и производительность (МС-МС)-анализов, а также их совместимость с различными методами разделения. Это, вероятно, приведет к значительным изменениям (МС-МС)-инструментов в ближайшем будущем.

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Короткий адрес: https://sciup.org/14264336

IDR: 14264336

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