Научные статьи \ Прикладные науки. Медицина. Технология \ Инженерное дело. Техника в целом \ Общее машиностроение. Ядерная технология. Электротехника. Технология машиностроения \ Электротехника

Тандемные масс-спектрометры в биохимии

Тандемные масс-спектрометры в биохимии

Автор: Веренчиков А.Н., Краснов Н.В., Галль Л.Н.

Журнал: Научное приборостроение @nauchnoe-priborostroenie

Рубрика: Масс-спектрометрия для биотехнологии

Статья в выпуске: 2 т.14, 2004 года.

Бесплатный доступ

В обзоре кратко рассмотрена история развития тандемной масс-спектрометрии (МС-МС) и выявлен быстрый прогресс в этой области, особенно в последнее десятилетие. Инструментальные аспекты МС-МС затронуты при описании принципов и аналитических характеристик наиболее популярных тандемов. Показан ряд приложений МС-МС в различных областях "науки о жизни", включая фармацевтику и протеомику. Особое внимание уделено динамике развития области и взаимному влиянию инструментальной базы и приложений. Значительный прогресс в развитии тандемных инструментов, как и революционный взрыв в биоинформатике сделали МС-МС наиболее чувствительным и специфическим и, как следствие, предпочтительным аналитическим методом в биохимии. В свою очередь биотехнология создала значительный рынок для (МС-МС)-приборов и стала существенно влиять на их развитие. В обзоре сделан акцент на то, что биотехнологи работают со сложными смесями (до 10^6 компонент), в большом динамическом диапазоне концентраций (до 10^6). Природа биотехнологических задач требует еще более совершенной (МС-МС)-аппаратуры, способной обеспечить более высокую чувствительность, специфичность и производительность (МС-МС)-анализов, а также их совместимость с различными методами разделения. Это, вероятно, приведет к значительным изменениям (МС-МС)-инструментов в ближайшем будущем.

Еще

Короткий адрес: https://sciup.org/14264336

IDR: 14264336   |   УДК: 621.384.668.8

Tandem mass spectrometry in biochemistry

The work presents a brief historical review of tandem mass spectrometry (MS-MS), indicating a vast progress in the field during the last decade. Instrumentation aspects are touched while describing basic principles of operation as well as analytical characteristics of the most popular tandems. Various applications of MS-MS in the filed of life science are overviewed, including drug discovery and proteomics. The review is mostly concerned with the logics of the field evolution and a mutual relation between instrumentation and applications. Recent advances in tandem mass spectrometry as well as revolutional leap in bioinformatics has made MS-MS the most specific and the most sensitive tool and a tool of choice for biochemical analysis. In return, life science became the major customer and a very noticeable driving force in the instrumentation development. The review highlights the fact that life science deals with very complex mixtures containing up to 10^6 components in a wide dynamic range of concentrations, up to 10^6. The nature of biochemical problems requires even higher sensitivity, specificity and throughput of MS-MS, and its compatibility with a wide range of separation tools, which is likely to cause further dramatic changes in MS-MS instrumentation.

Еще

Список литературы Тандемные масс-спектрометры в биохимии

  • Futrell J.H., Miller C.D.//Rev. Sci. Instrum. 1966. V. 37. P. 1521.
  • Futrell J.H. Development of tandem mass spectrometry: one perspective//Int. J. of Mass Spectrom. 2000. V. 200. P. 495-508.
  • Tandem Mass Spectrometry/Ed. McLafferty F.W. NY, John Willey & Sons, 1983.
  • McLafferty F.W., Todd P.J., McGilvery D.C., Baldwin M.A. High resolution tandem mass spectrometer (MS-MS) of increased sensitivity and mass range//J. Am. Chem. Soc. 1980. V. 102. P. 3360-3363.
  • Beynon J.H., Cooks R.G., Amy J.W. et al. Design and Performance of a mass analyzed ion kinetic energy spectrometer//Anal. Chem. 1973. V. 45. P. 1023A-1027A.
  • Futrell J.H. Interactions Between Ions and Molecules/Ed. Ausloos P. Plenum: New York, 1975.
  • Yost R.A., Enke C.G. Selected Ion fragmentation with a quadrupole mass spectrometer//J. Am. Chem. Soc. 1978. V. 100. P. 2274-2275.
  • Werlihy W.C., Royal N.J., Bieamann K. et al. Mass Spectra of partial protein hydrolysates as a multiple check for long polypeptides deduced from DNA sequences: NH2 -terminal segment of alanine tRNA synthetase//Proc. Natl. Acad. Sci. USA. 1980. V. 77. P. 6531-6535.
  • Aebersold R. and Mann M. Mass spectrometry-based proteomics//Nature. 2003. V. 422. P. 198-207.
  • Macfarlane R.D., Torgerson D.F., Chung K. et al.//Cyclotron Institute Progress Report. Texas A&M University, 1973-1974. P. 78-80.
  • Macfarlane R.D., Torgerson D.F.//Science. 1976. V. 191. P. 920.
  • Танцырев Г.Д., Разников В.В.//ДАН. 1964. т. 159. С. 182.
  • Liquid Chromatography Mass Spectrometry. Techniques and Applications/Eds.: Vestal M.L., Yergey A.L., Edmonds C.G., Lewis I.A.S. NY.: Plenum Press, 1990. 316 p.
  • Barber M., Bordoli R.S., Sedgwick R.D., Tyler A.N. Fast Atom Bombardment of solids as an ion source in mass spectrometry//Nature. 1981. V. 293. P. 270-275.
  • Barber M., Bordoli R.S., Sedgwick R.D., Tyler A.N. Fast Atom Bombardment (F.A.B.): A new Ion source in mass spectrometry//J. Chem. Soc. Chem. Commun. 1981. N 7. P. 325-327.
  • Caprioli R.M., Fan T., Cottrell J.S. Continuous-flow sample probe for fast atom bombardment mass spectrometry//Anal. Chem. 1986. V. 58. P. 2949-2954.
  • Iribarne J.V., Dziedic P.J. and Thomson B.A. Atmospheric Pressure Ion Evaporation Mass Spectrometry//Int. J. Mass Spectrom. Ion Phys. 1983. V. 50. P. 331-347.
  • Johnson O.N., Yost R.A. Tandem mass spectrometry for trace analysis//Anal. Chem. 1985. V. 57. P. 758A-768A.
  • Hunt D.F., Yates J.R., Shabanowitz J., Winston S. and Hauer C.R. Protein sequencing by tandem mass spectrometry//Proc. Natl. Acad. Sci. USA. 1986. V. 83. P. 6233-6237.
  • Александров М.Л., Галь Л.Н., Краснов Н.В. и др. Экстракция ионов из растворов при атмосферном давлении -новый способ масс-спектрометрического анализа биоорганических веществ//ДАН. 1984. т. 277, № 2. с. 379-383.
  • Александров М.Л., Галь Л.Н., Краснов Н.В. и др. Прямая стыковка микроколоночного жидкостного хроматографа с масс-спектрометром//Биоорганическая химия. 1984. т. 10, № 5. с. 710-712.
  • Александров М.Л., Галь Л.Н., Краснов Н.В. и др. Метод масс-спектрометрического анализа труднолетучих термически нестабильных веществ, основанный на экстракции ионов из раствора при атмосферном давлении//ЖАХ. 1985. т. 40, № 6. с. 160-172.
  • Whitehouse C.M., Dreyer R.N., Yamashita M. and Fenn J.B. Electrospray Interface for liquid chromatographs and mass spectrometers//Anal. Chem. 1985. V. 57. P. 675-679.
  • Fenn J.B., Mann M., Meng C.K., Wong S.F. and Whitehouse C.M. Electrospray ionization for mass spectrometry of large biomolecules//Science. 1989. V. 246. P. 64-71.
  • Tanaka K., Waki H., Ido Y. et al.//Rapid Commun. Mass Spectrom. 1988. N 2. P. 151.
  • Karas M. and Hillenkamp F. Laser desorption ionization of proteins with molecular masses exceeding 10000 daltons//Anal. Chem. 1988. V. 60. P. 2299-2301.
  • Electrospray Ionization Mass Spectrometry: Fundamentals, Instrumentation and Applications/Ed. Cole R.B. NY.: Willey, 1997.
  • Mass spectrometry in the Biological Sciences/Eds. Burlingame A.L., Carr S.A. NY.: Human Press.
  • Burlingame A. L., Boyd R.K. and Gaskell S.J. Mass spectrometry//Anal. Chem. 1998. V. 70. P. 647R-716R.
  • Spengler B., Kirsch D., Kaufmann R. and Jaeger E. Peptide sequencing by matrix-assisted laser-desorption mass spectrometry//Rapid Commun. Mass Spectrom. 1992. N 6. P. 105-108.
  • Kaufmann R., Chaurand P., Kirsch D. and Spengler B. Post-source decay and delayed extraction in matrix-assisted laser desorption/ionization-reflectron time-of-flight mass spectrometry. Are there trade-offs?//Rapid Commun. Mass Spectrom. 1996. N 10. P. 1199-1208.
  • Covey T.R., Lee E.D., Henion J.D. High Speed Liquid chromatography/tandem/mass spectrometry for the determination of drugs in biological samples//Anal. Chem. 1986. V. 58. P. 2453-2460.
  • Bruins A.P., Covey T.R., Henion J.D. Ion Spray Interface for combined liquid chromatography/atmospheric pressure ionization mass spectrometry//Anal. Chem. 1987. V. 59. P. 2642-2646.
  • Lee M.S. LC/MS applications in Drug Development//J. Willey Interscience. NY., 2002.
  • Emmett M.R., Caprioli R.M. Microelectrospray mass spectrometry: ultra high sensitivity analysis of peptides and proteins//JASMS. 1994. N 5. P. 605-613.
  • Shevchenko A., Jensen O.N., Podtelejnikov A.V. et al. Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels//Proc. Natl. Acad. Sci. USA, 1996. V. 93. P. 14440-14445.
  • Shevchenko A., Wilm M., Vorm O. and Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels//Anal. Chem. 1996. V. 68. P. 850-858.
  • Edman P. A method for the determination of the amino acid sequence of peptides//Arch. Biochem. Biophys. 1949. V. 22. P. 475-483.
  • Hunt D.F., Zhu N.Z., Shbanovich J. Oligopeptide sequence analysis by collision activated disssociation of multiply charged ions//Rapid Comm Mass Spectrom. 1989. V. 3, N 4. P. 122-124.
  • Covey T.R., Huang E.C., Henion J.D. Structural Characterization of protein tryptic peptides via liquid chromatography/mass spectrometry and collision induced dissociation of their doubly charged molecular ions//Anal. Chem. 1991. V. 63. P. 1193-1200.
  • Yates J.R., Yates III., Speicher S., Griffin P.R., Hunkapiller T. Peptide mass maps: a highly informative approach to protein identification//Anal. Biochem. 1993. V. 214. P. 397-408.
  • Yates J.R., Yates III. Mass spectrometry and the age of the proteome//J. Mass Spectrom. 1998. V. 33. P. 1-19.
  • Pappin D.D., Hojrup P. and Bleasby A.J. Rapid identification of proteins by peptide-mass finger printing//Curr. Biol. 1993. N 3. P. 327-332.
  • Mann M., Hojrup P. and Roepstorff P. Use of mass spectrometric molecular weight information to identify proteins in sequence databases//Biol. Mass Spectrom. 1993. V. 22. P. 338-345.
  • Vestal M.L., Juhasz P., Martin S.A.//Rapid Commun. Mass Spectrom. 1995. N 9. P. 1044.
  • Juhasz P., Vestal M.L., Martin S. Optimization Startegies in Delayed Extraction MALDI TOF//Extended abstract of ASMS conference 1997 (www.asms.org).
  • Loboda A.V., Krutchinsky A.N., Bromirski M. et al. A tandem quadrupole/time-of-flight mass spectrometer with a matrix-assisted laser desorption/ionization source: design and performance//Rapid Commun. Mass Spectrom. 2000. N 14. P. 1047-1057.
  • Verentchikov A., Smirnov I. and Vestal M.L. Collisional Cooling and Ion Formation Processes in orthogonal MALDI at Intermediate Gas Pressure//Extended abstract of ASMS conference 1999 (www.asms.org).
  • Smirnov I., Haff L., Vetsal M.L. and Verentchikov A.N. Orthogonal MALDI in the Analysis of proteins and DNA//Extended abstract of ASMS conference 1999 (www.asms.org).
  • www.appliedbiosystems.com
  • Miller P.E., Denton M.B. The quadrupole mass filter: basic operating concepts//J. Chem. 1986. V. 63. P. 617-622.
  • Douglas D.J., French J.B.//J. Am. Soc. Mass Spectrom. 1992. N 3. P. 398.
  • Carr S.A., Huddleston M.J. and Annan R.S. Selective detection and sequencing of phosphopeptides at the femtomole level by mass spectrometry//Anal. Biochem. 1996. V. 239. P. 180-192.
  • Wilm M. and Mann M. Analytical properties of the nanoelectrospray ion source//Anal. Chem. 1996. V. 68. P. 1-8.
  • Morris H.R., Paxton T., Dell A. et al. High sensitivity collisionally-activated decomposition tandem mass spectrometry on a novel quadrupole/orthogonal-acceleration time-of-flight mass spectrometer//Rapid Commun. Mass Spectrom. 1996. N 10. P. 889-896.
  • Morris H.R., Paxton T., Panico M. et al. A novel geometry mass spectrometer, the Q-TOF for low-femtomole/attomole-range biopolymer sequencing//J. Protein Chem. 1997. N 16. P. 469-479.
  • Shevchenko A., Chernushevich I., Ens W. et al. Rapid "de novo" peptide sequencing by a combination of nanoelectrospray, isotopic labeling and a quadrupole/timeof-flight mass spectrometer//Rapid Commun. Mass Spectrom. 1997. N 11. P. 1015-1024.
  • March R.E., Hughes R.J. Quadrupole storage mass spectrometry. NY.: Willey-Interscience, 1989.
  • www.thermofinnigan.com
  • Cooks R.G., Glish G.L., McLuckey S.A. and. Kaiser E.R. Ion trap mass spectrometry//Chem. Eng. Newsl. 1991. N 25. P. 26-41.
  • Yates J.R., Yates III., McCormack A.L. et al. Direct analysis of protein mixtures by tandem mass spectrometry//J. Protein Chem. 1997. N 16. P. 495-497.
  • Marshall A.G., Hendrickson C.L. and Jackson G.S. Fourier transform ion cyclotron resonance mass spectrometry: a primer//Mass Spectrom. Rev. 1998. N 17. P. 1-35.
  • Smith R.D., Pasa-Tolic L., Lipton M.S. et al. Rapid quantitative measurements of proteomes by Fourier transform ion cyclotron resonance mass spectrometry//Electrophoresis. 2001. N 22. P. 1652-1668.
  • Senko M.W., Hendrickson C.L., Pasa-Tolic L. et al.//Rapid Commun. Mass. Spectrom. 1996. V. 10. P. 1824-1828.
  • Horning S., Malek R., Wieghaus A., et al. A Hybrid two-Dimensional Quadrupole Ion Trap-Fourier Transform Ion Cyclotron Mass Spectrometer: Accurate Mass and High Resolution at a Chromatography Timescale//Extended abstract on ASMS conference 2003 (www.asms.org)
  • Conrads T.P., Anderson G.A., Veenstra T.D. et al.//Anal. Chem. 2000. V. 72. P. 3349.
  • Smith R.D., Anderson G.A., Lipton M.S. et al.//Proteomics. 2002. N 2. P. 513.
  • Strittmatter E.F., Ferguson P.L., Tang K. and Smith R.D. Proteome Analyses Using Accurate Mass and Elution Time Peptide Tags with Capillary LC Time-of-Flight Mass Spectrometry//J. Am. Soc. Mass Spectrom. 2003. N 14. P. 980-991.
  • Vestal M.L. Time-of-flight mass spectrometry analysis of biomolecules. US Patent 6541765, Filed 1998.
  • Vestal M.L. The future of time of-flight mass spectrometry//Extended abstract on ASMS 2002, ThOF 3:40 (www.asms.org).
  • www.bruker.com
  • Cornish T.J., Cotter R.J. High-order kinetic energy focusing in the end cup reflectron time-of-flight mass spectrometer//Anal. Chem. 1997. V. 69. P. 4615-4618.
  • Pramanik B.N., Bartner P.L., Chen G. The role of mass spectrometry in drug discovery process//Current Opinion in Drug Discovery. 1999. N 2. P. 401-417.
  • Applied Electrospray Mass Spectrometry/Eds. Pramanik B.N., Ganguly A.K., Gross M.L. NY.: Marcel Dekker, 2001.
  • Banerjee P.K., Rosofsky M. Drug discovery: the quest for innovation and productivity//Scrip Magazine. November 1997. P. 35-38.
  • Taylor L.C.E., Johnson R.L., Raso R. Open-access atmospheric pressure chemical ionization mass spectrometry for routine sample analysis//J. Am. Soc. Mass Spectrom. 1995. N 6. P. 387-393.
  • Gallop M.A., Barrett R.W., Dower W.J., Fodor S.P., Gordon E.M. Application of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries//J. Med. Chem. 1994. V. 37. P. 1233-1251.
  • Gordon E.M., Barrett R.W., Dower W.J. et al. Application of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screenings strategies, and future directions//J. Med. Chem. 1994. V. 37. P. 1385-1401.
  • Davis R.G., Anderegg R.G., Blanchard S.J. Iterative size-exclusion chromatography coupled with liquid chromatographic mass spectrometry to enrich and identify tight binding ligands from complex mixtures//Tetrahedron. 1999. V. 55. P. 1653-1667.
  • Enjabal C., Martinez J., Aubagnac J.L. Mass Spectrometry in Combinatorial Chemistry//Mass Spectrom. Rev. 2000. N 19. P. 139-161.
  • Susmuth R.D., Yang G. Impact of mass spectrometry on combinatorial chemistry//J. Chromatogr. B. Biomed, Sci. Appl. 1999. V. 725. P. 49-65.
  • Zeng L., Kussel D.B. Developments of fully automated parallel HPLC mass spectrometry system for the analytical characterization and preparative purification of combinatorial libraries//Anal. Chem. 1998. V. 70. P. 4380-4388.
  • Davis M.T. and Lee T.D. Rapid protein identification using a microscale electrospray LC/MS system on an ion trap mass spectrometer//J. Am. Soc. Mass Spectrom. 1998. N 9. P. 194-201.
  • Van Breeman R.B., Huang C.R., Nikolic D. et al. Pulsed ultrafiltration mass spectrometry: a new method for screening combinatorial libraries//Anal. Chem. 1997. V. 69. P. 2159-2164.
  • Blom K.F., Combs A.P., Rockwell A.L. et al. Direct mass spectrometry determination of bead bound compounds in a combinatorial lead discovery application//Rapid Commun. Mass Spectrom. 1998. N 12. P. 1192-1198.
  • Pullen F.S., Kerkins G.L., Barton K.I. et al. Putting mass spectrometry in the hands of the end user//J. Am. Soc. Mass Spectrom. 1995. N 6. P. 394-399.
  • Lane S.J., Pipe A. A single generic microbore liquid chromatography -time-of-flight mass spectrometry solution for the simultaneous accurate mass determination of compounds on single beads, the decoding of dansylated orthogonal tags pertaining to compounds and accurate isotopic difference target analysis//Rapid Commun. Mass Spectrom. 1999. N 13. P. 798-814.
  • Fang A.S., Vouros P., Stacey C.C. et al. Rapid characterization of combinatorial libraries using electrospray Fourier transform ion cyclotron resonance mass spectrometry//Comb. Chem. High Throughput Screen. 1998. N 1. P. 23-33.
  • Fitch W.L. Analytical Methods for quality control of combinatorial libraries//Mol. Divers. 1998/1999. N 4. P. 39-45.
  • Zeng L., Burton L., Young K., Shushan B., Kussel D.B. Automated analytical-preparative HPLC mass spectrometry system for rapid characterization and purification of combinatorial libraries//J. Chromatogr. A. 1998. V. 794. P. 3-13.
  • www.waters.com
  • Dе Biasi V., Haskins N., Organ A. et al. High throughput liquid chromatography -mass spectrometric analyses using a novel multiplexed electrospray interface//Rapid. Comm. Mass Spectrom. 1999. N 12. P. 1165-1168.
  • Wang T., Zheng L., Strader T. et al. A new ultra-high throughput method for characterizing combinatorial libraries incorporating a multiple probe autosampler coupled with flow injection mass spectrometry analysis//Rapid Comm. Mass Spectrom. 1998. N 12. P. 1123-1129.
  • Tong H., Bell D., Keiko T., Siegal M.M. Automated data massaging and e-mailing for high throughput open access mass spectrometry//J. Am. Soc. Mass Spectrom. 1990. N 10. P. 1174-1187.
  • Huang N., Siegel M.M., Kruppa G.H., Laukien F.H. Automation of Fourier transform ion cyclotron resonance mass spectrometer for acquisition, analysis, and e-mailing of high resolution exact mass electrospray ionization mass spectral data//J. Am. Soc. Mass Spectrom. 1999. N 10. P. 1166-1173.
  • Richmond R., Gorlach E., Seifert J.M. High throughput flow injection analysis mass spectrometry with networked delivery of colour rendered results: the characterization of liquid chromatography fractions//J. Chromatogr. A. 1999. V. 835. P. 29-39.
  • Kyranos J.N., Hogan J.C. High Throughput characterizatrion of combinatorial libraries generated by parallel synthesis//Anal. Chem. 1998. V. 70. P. 389A-395A.
  • Weller H.N., Young M.G., Michalczuk S.J. et al. High throughput analysis and purification in support of automated parallel synthesis//Mol. Divers. 1997. N 3. P. 61-70.
  • Weller H.N. Purification of combinatorial libraries//Mol. Divers. 1998/1999. N 4. P. 47-52.
  • Korfmacher W.A., Palmer C.A., Nardo C. et al. Development of an autoimated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability//Rapid Comm. Mass Spectrom. 1999. N 13. P. 901-907.
  • Olah T.V., McLoughlin D.A., Gilbert J.D. The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure//Rapid Comm. Mass Spectrom. 1997. N 11. P. 17-23.
  • Beaudry F., Yves J.C., Le Blanc, Coutu M., Brown N.K. In vivo pharmacokinetic screening in cassette dosing experiments: the use of on-line prospekt (R) liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry technology in drug discovery//Rapid Comm. Mass Spectrom. 1998. N 12. P. 1216-1222.
  • Perchalski R.J., Yost R.A., Wilder B.J. Structural Elucidation of drug metabolism by triple quadrupole mass spectrometry//Anal. Chem. 1982. V. 54. P. 1466-1471.
  • Corthals G.L., Wasinger V.C., Hochstrasser D.F. and Sanchez J.C. The dynamic range of protein expression: a challenge for proteomic research//Electrophoresis. 2000. N 21. P. 1104-1115.
  • Dunham I., Shimizu N., Roe B.A. et al. The DNA sequence of human chromosome 22//Nature. 1999. V. 402. P. 489-495.
  • Broder S. and Venter J.C. Sequencing the entire genomes of free-living organisms: the foundation of pharmacology in the new millennium//Annu. Rev. Pharmacol. Toxicol. 2000. V. 40. P. 97-132.
  • Venter J.C., Adams M.D., Myers E.W. et al. The sequence of the human genome//Science. 2001. V. 291. P. 1304-1351.
  • O'Farrell P.H. High resolution two-dimensional electrophoresis of proteins//J. Biol. Chem. 1975. V. 250. P. 4007-4021.
  • Anderson N.G. and Anderson N.L. Twenty years of two-dimensional electrophoresis: past, present and future//Electrophoresis. 1996. N 17. P. 443-453.
  • Appel R.D., Bairoch A. and Hochstrasser D.F. 2-D databases on the World Wide Web//Me thods Mol. Biol. 1999. V. 112. P. 383-391.
  • Dunn M.J. Studying heart disease using the proteomic approach//Drug Discov. Today. 2000. N 5. P. 76-84.
  • Scheler C., Li X.P., Salnikow J. et al. Comparison of two-dimensional electrophoresis patterns of heat shock protein Hsp27 species in normal and cardiomyopathic hearts//Electrophoresis. 1999. N 20. P. 3623-3628.
  • Zhang W., Czernik A.J., Yungwirth T. et al. Matrix-assisted laser desorption mass spectrometric peptide mapping of proteins separated by two-dimensional gel electrophoresis: determination of phosphorylation in synapsin//J. Protein Sci. N 3. P. 677-686.
  • Jensen O.N., Podtelejnikov A.V. and Mann M. Identification of the components of simple protein mixtures by high-accuracy peptide mass mapping and database searching//Anal. Chem. 1997. V. 69. P. 4741-4750.
  • Zhang W., Chait B.T. ProFound: an expert system for protein identification using mass spectrometric peptide mapping information//Anal. Chem. 2000. V. 72. P. 2482-2489.
  • Krutchinski A.N., Zhang W. and Chait B.T. Ra pidly switchable matrix-assisted laser desorption/ionization and electrospray quadrupoletime-of-flight mass spectrometry for protein identification//J. Am. Soc. Mass Spectrom. 2000. N 11. P. 493-504.
  • Griffin T.J., Gygi S.P., Rist B. et al. Quantitative proteomic analysis using a MALDI quadrupole time-of-flight mass spectrometer//Anal. Chem. 2001. V. 73. P. 978-986.
  • Mann M. and Wilm M. Error-tolerant identification of peptides in sequence databases by peptide sequence tags//Anal. Chem. 1994. V. 66. P. 4390-4399.
  • Sunyaev S., Liska A.J., Golod A. et al. MultiTag: Multiple Error tolerant sequence tag search for the sequence similarity identification of proteins by mass spectrometry//Anal. Chem. 2003. V. 75. P. 1307-1315.
  • Opiteck G.J., Lewis K.C., Jorgenson J.W. and Anderegg R.J. Comprehensive on-line LC/LC/MS of proteins//Anal. Chem. 1997. V. 69. P. 1518-1524.
  • Gygi S.P., Gorthals G.L., Zhang Y. et al.//Proc. Natl. Acad. Sci. USA. 2000. V. 97. P. 9390.
  • Peng J., Gygi S.P. Proteomics: the move to mixtures//J. Mass Spectrom. 2001. N 36. P. 1083-1091.
  • Deterding L.J., Moseley M.A., Tomer K.B. and Jorgenson J.W. Nanoscale separations combined with tandem mass spectrometry//J. Chromatogr. 1991. V. 554. P. 73-82.
  • Wilm M., Shevchenko A., Houthaeve T. et al. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry//Nature. 1996. V. 379. P. 466-469.
  • Hunt D.F., Henderson R.A., Shabanowitz J. et al. Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry//Science. 1992. V. 255. P. 1261-1263.
  • Gygi S.P., Rist B., Gerber S.A. et al. Quantitative analysis of complex protein mixtures using isotope coded affinity tags//Nat. Biotechnol. 1999. N 17. P. 994-999.
  • Smolka M.B., Zhou H., Purkayastha S. and Aebersold R. Optimization of the isotope-coded affinity tag-labeling procedure for quantitative proteome analysis//Anal. Biochem. 2001. V. 297. P. 25-31.
  • Goffeau A., Barrell B.G., Bussey H. et al. Life with 6000 genes//Science. 1996. V. 274. P. 546, 563-567.
  • Newman A. RNA splicing//Curr. Biol. 1998. N 8. P. R903-R905.
  • Gygi S.P., Rochon Y., Franza B.R. and Aebersold R. Correlation between protein and mRNA abundance in yeast//Mol. Cell. Biol. 1999. N 19. P. 1720-1730.
  • Eisenberg D., Marcotte E.M., Xenarios I. and Yeates T.O. Protein function in the post-genomic era//Nature. 2000. V. 405. P. 823-826.
  • Krishna R.G. and Wold F. Post-translational modification of proteins//Adv. Enzymol. Relat. Areas Mol. Biol. 1993. V. 67. P. 265-298.
  • Pandey A. and Mann M. Proteomics to study genes and genomes//Nature. 2000. V. 405. P. 837-846.
  • Eisenstein E., Gilliland G.L., Herzberg O. et al. Biological function made crystal clear -annotation of hypothetical proteins via structural genomics//Curr. Opin. Biotechnol. 2000. N 11. P. 25-30.
  • MacBeath G. and Schreiber S.L. Printing proteins as microarrays for high-throughput function determination//Science. 2000. V. 289. P. 1760-1763.
  • Blackstock W.P. and Weir M.P. Proteomics: quantitative and physical mapping of cellular proteins//Trends Biotechnol. 1999. N 17. P. 121-127.
  • Jung E., Heller M., Sanchez J.C. and Hochstrasser D.F. Proteomics meets cell biology: the establishment of subcellular proteomes//Electrophoresis. 2000. N 21. P. 3369-3377.
  • Oda Y., Nagasu T., Chait B.T. Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome//Nat. Biotechnol. 2001. N 19. P. 379-382.
  • Neubauer G. and Mann M. Mapping of phosphorylation sites of gel-isolated proteins by nano electrospray tandem mass spectrometry: potentials and limitations//Anal. Chem. 1999. V. 71. P. 235-242.
  • Goshe M.B., Conrads T.P., Panisko E.A. et al. Phosphoprotein isotope-coded affinity tag approach for isolating and quantitating phosphopeptides in proteome-wide analyses//Anal. Chem. 2001. V. 73. P. 2578-2586.
  • Graves P.R. and Haystead T.A.J. Molecular Biologist's Guide to Proteomics//Microbiology Mol. Biology Rev. March 2002. p. 39-63.
  • Schena M., Shalon D., Davis R.W. and Brown P.O. Quantitative monitoring of gene expression patterns with a complementary DNA microarray//Science. 1995. V. 270. P. 467-470.
  • Haynes P.A. and Yates III. Proteome profiling-pitfalls and progress//Yeast. 2000. N 17. P. 81-87.
  • Celis J.E., Ostergaard M., Rasmussen H.H. et al. A comprehensive protein resource for the study of bladder cancer//Electrophoresis. 1999. N 20. P. 300-309; http://biobase.dk/cgi-bin/celis
  • Heinke M.Y., Wheeler C.H., Yan J.X. et al. Changes in myocardial protein expression in pacing-induced canine heart failure//Electrophoresis. 1999. N 20. P. 2086-2093.
Еще
QR-код для установки приложения SciUp Наведите камеру и скачайте бесплатное приложение SciUp