Course and outcome of pregnancy in women with hyperhomocysteinemia with various initial folate therapy

The study provides a comparative evaluation of pregnancy course, perinatal pathology, and catamnesis of infants born to mothers with hyperhomocysteinemia who received corrective therapy beginning from the pregravid phase (two months before the planned pregnancy) or the first regular medical check-up for pregnancy (9.9±0.54 weeks of pregnancy). Pregnancy complications such as the threatened abortion, placental insufficiency, preeclampsia, the syndrome of fetus developmental delay, lower assessment of newborn according to the Apgar score, high incidence of hypoxic ischemic lesions of the central nervous system, hypertensive hydrocephalic syndrome, and impaired speech development were found more often in women who started the folate therapy at nine weeks of pregnancy.