The role of the system of insulin-like growth factors in blood in soft tissue sarcomas
Автор: Goroshinskaya I.A., Kaplieva I.V., Sagatelyan S.A., Frantsiyants E.M., Vashchenko L.N., Pogorelova Yu.A., Trepitaki L.K., Ausheva T.V., Chernogorov P.V.
Журнал: Cardiometry @cardiometry
Статья в выпуске: 24, 2022 года.
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Although soft tissue sarcomas (STS) belong to a group of rare diseases of mesenchymal origin, their characteristic tendency to recurrence and high mortality necessitates the search for some prognostic bio-markers to identify patients at risk of their recurrence [1]. In this regard, the system of insulinlike growth factors (IGF) and their binding proteins (IGFBP) is of interest, since it has been established that dysregulation of the IGF system leads to the proliferation of cancer cells, migration and resistance to chemotherapy.
Короткий адрес: https://sciup.org/148326320
IDR: 148326320 | DOI: 10.18137/cardiometry.2022.24.conf.27
Список литературы The role of the system of insulin-like growth factors in blood in soft tissue sarcomas
- Pillozzi S., Bernini A., Palchetti I. et al. Soft Tissue Sarcoma: An insight on biomarkers at molecular, metabolic and cellular level. Cancers (Basel), 2021, v. 13(12): 3044.
- Mancarella C, Morrione A, Scotlandi K. Unraveling the IGF system interactome in sarcomas exploits novel therapeutic options. Cells, 2021, v; 10(8): 2075.
- Tombolan L., et al. High IGFBP2 expression correlates with tumor severity in pediatric rhabdomyosarcoma. Am J Pathol., 2011, v. 179, p. 2611-2624.
- Tang D., Yao R., Zhao D. et al. Trichostatin A reverses the chemoresistance of lung cancer with high IGFBP2 expression through enhancing autophagy. Sci Rep., 2018, v. 8: 3917.
