The state of anti-oxidation system in rats under chemically induced cancerogenesis and influence by complexly modulated ultra-low frequency magnetic field (ULF MF)

Kit Oleg I.; Shikhlyarova Alla I.; Frantsiyants Elena M.; Cheryarina Natalia D.; Tkalya Lyudmila D.

doi:10.12710/cardiometry.2017.11.2834

Scientific articles \ Applied sciences. Medicine. Technology \ Medical sciences \ Pharmacology. Therapeutics. Toxicology

The state of anti-oxidation system in rats under chemically induced cancerogenesis and influence by complexly modulated ultra-low frequency magnetic field (ULF MF)

Kit Oleg I. Shikhlyarova Alla I. Frantsiyants Elena M. Cheryarina Natalia D. Tkalya Lyudmila D.

Journal: Cardiometry @cardiometry

Section: Original research

Article in issue: 11, 2017.

Free access

At present, control of properties of biological membranes as targets of magnetic field applications within a living cell is the subject of considerable discussion in the scientific community. Experimental studies carried out by us demonstrate that ULF MF has an access to the most important mechanisms of tumor growth. The most likely mechanism among them is that responsible for the processes of free-radicals oxidation. Therefore, our research work was aimed at studies of influences of ULF MF on indicators of the anti-oxidation system in blood plasma and blood cells in rats in the chemically induced cancerogenesis. Our experimental studies were performed in 45 outbred albino male rats having a body mass from 160 to 180 g. The state of the anti-peroxidation protection of cell membranes was assessed by indicators of the fermentation subsystem of AOS (catalase, TPA, SOD), and the state of the non-fermentive subsystem of AOS was estimated by indicators of the concentrations of vitamins A and E in blood serum...

chemically induced cancerogenesis \ ulf mf \ antioxidation system

Similar articles in the section Pharmacology. Therapeutics. Toxicology

The effect of diabetes mellitus under tumor growth on respiratory function and free radical processes in heart cell mitochondria in rats

Frantsiyants E.M., Neskubina I.V., Shikhlyarova A.I., Cheryarina N.D., Kaplieva I.V., Bandovkina V.A., Trepitaki L.K., Nemashkalova L.A., Lysenko I.B., Kachesova P.S., Sheiko E.A., Morozova M.I., Kotieva I.M.

State of free-radical processes in the heart cell mitochondria under melanoma В16/F10 growth against the background of chronic neurogenic pain as comorbid pathology

Frantsiyants E.M., Neskubina I.V., Shikhlyarova A.I., Surikova E.I., Trepitaki L.K., Nemashkalova L.A., Bandovkina V.A., Kaplieva I.V., Rozenko L.Y., Dimitriadi S.N.

Influence of standard and stimulated growth of B16/F10 melanoma on AIF levels in mitochondria in cells of the heart and other somatic organs in female mice

Kit O.I., Frantsiyants E.M., Neskubina I.V., Cheryarina N.D., Shikhlyarova A.I., Przhedetskiy Y.V., Pozdnyakova V., Surikova E.I., Kaplieva I.V., Bandovkina V.A.

Morphologic correlates of the multimodal electromagnetic exposures efficiency (as exemplified by the experiment tumor growth)

Barteneva Tatiana A., Shikhlyarova Alla I., Zhukova Galina V., Protasova Tatiana P., Bragina Marina I., Shirnina Elena A.

Pathogenetic substantiation for anti-tumor effectiveness of experimental electromagnetic therapy

Kit Oleg I., Komarova Ekaterina F., Shikhlyarova Alla I., Korobeinikova Elena P., Vanzha Ludmila V., Pozdnyakova Viktoria V., Dashkov Andrey V., Frantsiyants Elena M.

The pattern of the immune processes during activation therapy with the use of microwave electromagnetic radiation

Zhukova Galina V., Shikhlyarova Alla I., Barteneva Tatiana A., Bragina Marina I., Gudtskova Tatiana N., Petrosyan Vladimir M., Shirnina Elena A., Zlatnik Elena Yu., Korobeinikova Elena P.

Short address: https://sciup.org/148308830

IDS: 148308830 | DOI: 10.12710/cardiometry.2017.11.2834

References The state of anti-oxidation system in rats under chemically induced cancerogenesis and influence by complexly modulated ultra-low frequency magnetic field (ULF MF)

Tenuzzo B, Chionna A, Panzarini E, et al. Biological effects of 6 mT of static magnetic fields: a comparative study in various types of cells. Bioelectromagnetics. 2006;27(7):560-77 DOI: 10.1002/bem.20252
Ghodbane S, Lahbib A, Ammary M, Sakly M, Abdelmelek H. Lee static magnetic field exposure induced by oxidative stress and apoptosis in the kidney and muscle of rats? Effect of vitamin E and selenium supplementations. Gen Physiol Biophys. 2015;34(1):23-32 DOI: 10.4149/gpb_2014027
Ghodbane S, Amara S, Garrel C, et al. Selenium supplements improves static magnetic field disturbances induced in antioxidant status in the tissues of rats. Environ Toxicol Pharmacol. 2011;31(1):100-6. DOI:10.1016/j.etap.2010.09.010.
Kiprianov A., Doctorov A, Purty R. Magnetic field effects on bistability and bifurcation phenomena in lipid peroxidation. Bioelectromagnetics. 2015 Oct; 36(7):485-93. DOI: 10.1002/bem.21934. Epub 2015 September 1
Garkavi LKh, Kvakina YeB, Shikhlyarova AI, et al. Magnetic fields, adaptational reaktions and the self-organization of living system. Biofizika, 1996;4(41):898-905.
Ciejka E, Kowalczyk, Gorąca. Influence of extremely low magnetic field frequency on total protein concentration and -SH groups in liver homogenates. Honey Pr. 2014; 65(5):639-44.
Kit OI, AI Shikhlyarova, Мaryanovskaya GY, et al. Theory of health: successful translation into the real life. Cardiometry. 2015;7:11-7.
Shikhlyarova AI, Мaryanovskaya GY, Barsukova LP, et al. Methodological fundamentals of experimental magneto-therapy of tumors (historical essay). Cardiometry. 2015;7:42-6.
Shihljarova AI. The role of biotropic parameters of electromagnetic fields in the increase of nonspecific antitumor resistance. Dissertation. Rostov-na-Donu, 2001, 50p.
Shihljarova AI, Mar'janovskaja GJa, Barsukova LP, Shejko EA, et al. Some results and prospects of experimental and clinical investigation of the antitumor effect of electromagnetic factors Izvestija vysshih uchebnyh zavedenij. Severo-kavkazskij region. 2011;111-114.
Francijanc EM. Peroxide oxidation of lipids in the pathogenesis of tumor disease. Dissertation. 1997. 44 p.
Shabad LM. Methods for studying the blastomogeneity of chemical substances. 1970. 240 p.
Ageenko AI. Hetero-transplantation of malignant tumors. Moscow, 1961.
Koroljuk MA, Ivanova LI, Majorova IG, Tokarev VE. Method for the determination of catalase activity. Lab. Delo. 1988;1:16-8.
Pokrovskij AA. Biochemical methods of research in the clinic. Moscow, 1969. p. 349-351.
Vnukov VV. Iron-containing proteins and proteolytic activity in blood serum with hyperoxia and protective action of urea. Dissertation. Har'kov, 1979.
Beauchamp C, Fridovich I. Superoxide dismutase: Improved assays and assayapplicable to acrylamide gels. Anal. Biochem. 1971;44:276-81.
Chernauskene RCh, Varshkjavichene ZZ, Gribauskas PS. Simultaneous fluorimetric determination of the concentration of vitamins E and A in serum. Lab. Delo. 1984;6:362-5.
Vladimirov JuA, Archakov AI. Peroxide oxidation of lipids in biological membranes. 1972. 252p.
Manojlov SE. To the history and evolution of views on the theoretical basis of the process of carcinogenesis. Voprosy onkologii. 1998;44:357-9.