Toxicological characterization of bupivacaine hydrochloride (Marcaine ®)

With the introduction intraperitoneal of marcaine in toxic doses clinic acute poisoning rats occurs after 2-3 minutes and 20-30 minutes ends with the death of animals.LD 50 marcaine per substance (bupivacaine hydrochloride) is 58,4 ± 3,4 mg / kg, the MTD-40 mg / kg, the LD 16-49,0 mg / kg, LD 100-80, 0 mg/kg. Cumulation coefficient is determined by the method Limm and al. еqual to 8.06.