Токсиколого-гигиеническая оценка наночастиц диоксида титана в составе пищевой добавки Е171 (обзор данных литературы и метаанализ)

Токсиколого-гигиеническая оценка наночастиц диоксида титана в составе пищевой добавки Е171 (обзор данных литературы и метаанализ)

Автор: Гмошинский И.В., Багрянцева О.В., Хотимченко С.А.

Журнал: Анализ риска здоровью @journal-fcrisk

Рубрика: Анализ риска здоровью в задачах организации здравоохранения

Статья в выпуске: 2 (26), 2019 года.

Бесплатный доступ

Рассматриваются данные о величинах экспозиции, биодоступности, эффектах токсичности и рисках наночастиц (НЧ) диоксида титана TiO2 при их поступлении в организм через желудочно-кишечный тракт (ЖКТ) в виде пищевой добавки - красителя Е171 либо как значимой примеси в ее составе. Согласно токсикологической оценке, данной JECFA в 1969 г., TiO2 рассматривался как малоопасное вещество. Однако в настоящее время ряд зарубежных и международных организаций в области безопасности пищи придерживаются мнения, что эта оценка должна быть пересмотрена в свете новых научных данных о неблагоприятном воздействии на организм TiO2 в наноформе. Суммарное поступление TiO2 в организм человека с пищевыми продуктами, косметическими средствами (зубные пасты) и лекарственными препаратами может составлять от 0,5 до 5,0 мг в сутки; наиболее экспонируемыми группами являются дети в возрасте 3-9 лет и подростки 10-17 лет. Несмотря на малую степень всасывания НЧ и микрочастиц TiO2 в ЖКТ, в значительном числе работ выявлены признаки их общетоксического действия на организм при пероральном и внутрижелудочном введении...

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Диоксид титана, пищевая добавка, наночастицы, экспозиция, биодоступность, токсичность, кишечный микробиоценоз, риски

Короткий адрес: https://sciup.org/142220678

IDR: 142220678   |   УДК: 613.23:   |   DOI: 10.21668/health.risk/2019.2.17

Toxicological and hygienic assessment of titanium dioxide nanoparticles as a component of E171 food additive (review of the literature and metahanalysis)

The review focuses on exposure values, biological availability, toxic effects, and risks caused by nanoparticles of TiO2 under their oral introduction into a body as a food coloring agent or E171 food additive, or as a significant component in its structure. According to toxicological assessment performed by JECFA in 1969, TiO2 is considered to be insignificantly hazardous. However, at present experts employed by several foreign and international organizations that deal with food safety believe that the assessment should be reviewed as there are new scientific data on adverse effects produced by nano-sized TiO2 on a human body. Overall intake of TiO2 by people with food products, cosmetics (tooth pastes) and medications can vary from 0.5 to 5 mg a day; children aged 3-9 and teenagers aged 10-17 are the most exposed population groups. Despite insignificant intestinal absorption of TiO2 nano- and micro-sized particles, a lot of scientific works revealed their overall toxic effects produced on a body under oral and intragastric introduction...

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