Concurrent incidence of esophageal squamous cell carcinoma and gastric adenocarcinoma: a report of three cases

The purpose of the study was to investigate rare cases of concurrent incidence of esophageal squamous cell carcinoma and gastric adenocarcinoma to develop an effective treatment strategy. Material and Methods. Herein, we present a report of three cases of simultaneous occurrence of esophageal squamous cell carcinoma and gastric adenocarcinoma treated at the Regional Clinical Oncology Center in Ulyanovsk and Sverdlovsk Regional Oncology Center in Yekaterinburg. The patients underwent surgery, chemotherapy and radiation therapy. Results. Synchronous esophageal squamous cell carcinoma and gastric adenocarcinoma pose significant treatment challenges, necessitating a multidisciplinary team of specialists. Chemoradiotherapy with the FOLFOX regimen demonstrated favorable tolerability and satisfactory clinical response. Conclusion. A multimodal approach, involving surgery and chemoradiotherapy with the FOLFOX scheme, may be a valuable option for the treatment of patients with synchronous esophageal squamous cell carcinoma and gastric adenocarcinoma.