Thrombotic properties of some nitrogen-containing substances

Among the drugs used to regulate the process of blood clotting, a fairy large portion contains amino groups or quaternary nitrogen atoms. From the point of view of influence on coagulation properties of blood their quantity and the spatial organization are of paramount importance for the realization of physiological functions of an organism. Therefore, the study of the mechanisms of thrombosis activation in different species is a necessary condition for the creation of new drugs of this action. In addition, in everyday life we face not only drugs, but also other substances that also have in their composition amino groups or quaternary nitrogen atoms, in particular, various food additives, household chemicals, pollutants and others substances, which undoubtedly contribute an environmental aspect to the problem under consideration. In the article we present the results of the investigation of the ability of various nitrogen-containing compounds (saturated, acetylene, aromatic and heteroaromatic amines, their hydrochlorides and quaternary ammonium salts), to accelerate coagulation (clotting) of the blood in mice carried out in vitro. It depends not only on the acid-base properties of the compounds, since hydrochlorides of amines and quaternary ammonium salts, which are not involved in acid-base interactions, also possess it. The maximum effect is shown by substances containing octyl substituting groups of normal structure in their composition. It is possible that the coordination ability of ligands with n-octyl groups in relation to Fe (II)-protoporphyrin IX, which is a part of hemoglobin, also plays an important role in enhancing the coagulation process. Due to the fact that many medications (especially intravenous) are amines, their salts or quaternary ammonium salts, we note that a significant part of them with prolonged use may increase the risk of thrombosis, even if at the moment such effects are not described for them. It is suggested that such compounds can be used as potential components of drugs for the treatment of diseases (for example, some types of hemophilia) associated with a reduced blood clotting ability.