Ultrastructure of bone apatite of the ramus of mandible in rats after 60‑day exposure to sodium benzoate or tartrazine and finding possibilities of correction of the state with Mexidol or Thiotriazolin

Objective: to establish changes in the ultrastructure of osteoapatite of the mandibular ramus in white rats during the readaptation period after 60‑day administration of sodium benzoate or tartrazine and to substantiate the possibility of correcting the identified changes with Mexidol or Thiotriazolin. Material and methods. The study involved 245 male rats distributed into intact animals, animals with sodium benzoate or tartrazine administration within 60 days before the beginning of observations and animals administered Mexidol or Thiotriazolin against the background of previous 60‑day exposure to sodium benzoate or Mexidol (7 groups in total). Results. Exposure to sodium benzoate and tartrazine led to disturbances of crystal lattice formation expressed throughout all observation periods. Administration of Mexidol against the background of sodium benzoate or tartrazine exposure was accompanied by signs of osteoapatite lattice restoration on 15 and 24 days — microtexture coefficient increased by 4.26 and 3.65 % respectively (р<0,05). When using Thiotriazolin under the same conditions the signs of lattice restoration were observed during all observation periods that is by 5.97, 6.25, 5.74, 5.97 and 5.87 % (р<0,05). Conclusion. In the study derangement of ultrastructure of biomineral of the mandibular ramus were found. Mexidol and Thiotriazolin have a positive effect on the formation of the crystal lattice, expressed in the restoration of its main parameters when prescribed against the background of chronic exposure to sodium benzoate or tartrazine.