Successful Management of Sepsis Following Liver Transplantation in an HIV-Positive Patient with Multiple Comorbidities: a case report

Introduction. Historically, HIV-infected patients were denied liver transplantation due to concerns about poorer outcomes compared to the non-infected population. Due to advances in antiretroviral therapy and improved understanding of the immunological status of these patients, transplantation has become a viable treatment option. Case Description. This report describes a 56-year-old HIV-positive man with multiple comorbidities who underwent liver transplantation for end-stage liver disease due to chronic hepatitis B. The early post-transplantation period was complicated by severe sepsis, multiple organ failure, and graft dysfunction. Treatment Methods. Comprehensive therapy included prolonged vasopressor support, renal replacement therapy, multiple blood transfusions, and targeted antimicrobial therapy. Results. The patient was successfully treated and discharged in stable condition with a functioning graft. Conclusion. This case demonstrates that even severe infectious complications after liver transplantation in polymorbid HIV-positive patients can be successfully treated with appropriate multidisciplinary intensive care.