Variants of thyroid dysfunction in patients with chronic hepatitis C from residents of the Altai region

Introduction. HCV is the cause of not only cirrhosis, hepatocellular carcinoma, but also of extrahepatic manifestations. Currently, HCV is considered as an independent risk factor for thyroid pathology. In recent years, the level of pathology of the thyroid gland in the Altai region has increased 16.4 times. It determined the study of the features of the thyroid status in patients with chronic hepatitis C (CHC) in the Altai region. Materials and Methods. A prospective, dynamic, clinical, laboratory and instrumental examination of 240 patients with CHC (47.5 % of men and 52.5 % of women aged 18 to 50 years) was carried out, 120 of them had HCV (49.1 % of men and 50, 9 % of women, aged 18 to 50 years, mean age 41.1 ± 9.91 years) who did not receive antiviral therapy (HTV), the pathology of the thyroid gland was identified for the first time the pathology of the thyroid gland. The study included the definition of TSH, general and free T3, T4, antibodies to thyreperoxidase (APPO), ultrasound examination of the thyroid gland. The diagnosis of CHC is based on: HCV RNA, anti-HCV (core, NS3-5), blood biochemistry, fibrosis level by Metavir (elastometry, PBP). Results. Autoimmune thyroiditis (AIT) (5 %), AIT with hypothyroidism (10 %), AIT with latent hypothyroidism (8.3 %), latent hypothyroidism (10 %), hypothyroidism (16.6 %), euthyroidism (49.1 %) and thyrotoxicosis (only 1 patient) were identified in patients with HCV Variants of thyroid dysfunction were presented in the form of euthyroidism (60 %), hypothyroidism (20 %), hyperthyroidism (10 %) and autoimmune thyroiditis (10 %). The relationship between the development of thyroid dysfunction (TD) and the history of HCV infection was identified. Discussion and Conclusions. The patients with CHC have euthyroidism and hypothy-roidism more often. The relationship of TD with the duration of HCV infection can be regarded as its extrahepatic manifestations, and not as comorbid conditions. Thorough examination of the thyroid status makes it possible to identify people with TD. It can be reflected in the choice of PVT and will determine the prognosis of the development of side effects.