Vasoprotective effect of classic ischemic preconditioning

It was established that ischemic preconditioning prevents the appearance of reperfusion endothelial dysfunction. However, the issue of preconditioning impact on noreflow phenomenon remains unresolved. The receptor mechanisms involved in the cardioprotective and vasoprotective effects of preconditioning are different. The ability of preconditioning in preventing reperfusion endothelial dysfunction is dependent upon bradykinin B2-receptors activation and is not dependent upon adenosine receptor stimulation. The vasoprotective effect of preconditioning is mediated via mechanisms relying in part on activation of protein kinase C, NOsynthase, cyclooxygenase, mitoKATP-channel opening and an enhancement of antioxidative protection of the heart.