Вазопротекторный эффект классического ишемического прекондиционирования

Автор: Маслов Л.Н., Крылатов А.В., Горбунов А.С., Цибульников С.Ю., Семенцов А.С.

Журнал: Сибирский журнал клинической и экспериментальной медицины @cardiotomsk

Статья в выпуске: 1 т.27, 2012 года.

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Установлено, что ишемическое прекондиционирование предупреждает возникновение реперфузионной эндотелиальной дисфункции. Однако вопрос о влиянии прекондиционирования на проявления феномена noreflow остается пока открытым. Рецепторные механизмы кардиопротекторного и вазопротекторного эффектов прекондиционирования различаются. Способность прекондиционирования предупреждать реперфузионную эндотелиальную дисфункцию связана с активацией брадикининовых В2-рецепторов и не зависит от стимуляции аденозиновых рецепторов. Вазопротекторный эффект прекондиционирования опосредован через механизмы, относящиеся к активации протеинкиназы С, NOсинтазы, циклооксигеназы, открытию митохондриальных КАТФ-каналов и усилению антиоксидантной защиты сердца.

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Сердце, реперфузионная эндотелиальная дисфункция, феномен noreflow, прекондициониро вание

Короткий адрес: https://sciup.org/14919709

IDR: 14919709

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